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(Hypertension. 2008;51:1611.)
© 2008 American Heart Association, Inc.

Original Articles

Angiotensin II in the Elderly

Impact of Angiotensin II Type 1 Receptor Sensitivity on Peripheral Hemodynamics

D. Walter Wray; Steven K. Nishiyama; Ryan A. Harris; Russell S. Richardson

From the Department of Medicine (D.W.W., S.K.N., R.A.H., R.S.R.), University of California San Diego, La Jolla; Division of Geriatrics, Department of Medicine (D.W.W., R.S.R.), and Department of Exercise and Sport Science (R.S.R.), University of Utah, Salt Lake City,; and the Geriatric Research and Clinical Center (R.S.R.), Veterans’ Affairs Medical Center, Salt Lake City, Utah.

Correspondence to D. Walter Wray, Department of Medicine, Physiology Division, 9500 Gilman Dr, University of California San Diego, La Jolla, CA 92093-0623. E-mail dwray{at}ucsd.edu

Exercise hyperemia is attenuated in the elderly, which may be attributed to local vasoregulatory pathways within the skeletal muscle vasculature. Therefore, we sought to determine whether healthy aging is associated with changes in angiotensin II (Ang II) receptor sensitivity through measurements of leg blood flow in resting and exercising skeletal muscle. In 12 (n=6 young, 24±1 years; n=6 older, 68±3 years) healthy volunteers, we determined changes in leg blood flow (ultrasound Doppler) before and during intra-arterial infusion of Ang II (0.8 ng/mL of leg blood flow per minute). Heart rate, arterial blood pressure, common femoral artery diameter, and mean blood velocity were measured at rest and during knee-extensor exercise at 20% and 40% of the maximal work rate (WR_max). At rest, Ang II infusion decreased leg blood flow to a greater extent in older (–61±8%) subjects compared with younger subjects (–31±5%). Compared with rest, Ang II–mediated vasoconstriction (leg blood flow) during exercise was diminished in both older and younger subjects at 20% (older: –7±5%; younger: –21±2%) and 40% WR_max (older: –5±4%; younger: –9±3%). These data identify a clear age-related hypersensitivity to Ang II in the resting leg, which may contribute to the recognized decrement in leg blood flow in this cohort. However, the diminished vasoconstriction to Ang II during exercise suggests that the elevation in Ang II type 1 receptor sensitivity documented at rest does not contribute significantly to the blunted exercise hyperemia experienced with advancing age.

Key Words: basic science • elderly • blood flow regulation • exercise • angiotensin receptors

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