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(Hypertension. 2009;54:e133.)
© 2009 American Heart Association, Inc.

Letters to the Editor

Long-Term Risk in Subjects With White-Coat Hypertension

Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan, Department of Pharmacy, Tohoku University Hospital, Sendai, Japan

Takayoshi Ohkubo

Departments of Clinical Pharmacology and Therapeutics and, Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan

Yutaka Imai

Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, Sendai, Japan

An extract of the first 250 words of the full text is provided, because this article has no abstract.

To the Editor:

We read with great interest the article by Mancia et al¹ clarifying the increased risk of developing sustained hypertension in subjects with white-coat hypertension, compared with normotensive patients, using home blood pressure measurements and ambulatory blood pressure monitoring. This study was performed over a 10-year period in the Pressioni Arteriose Monitorate e Loro Associazioni Study population.

Previously, we reported that subjects with white-coat hypertension are at increased risk of developing home hypertension, on the basis of home blood pressure measurements, during an 8-year follow-up period in the Ohasama Study.² We demonstrated that the odds ratio for white-coat hypertensive subjects to develop home hypertension was significantly higher compared with normotensives (odds ratio: 2.86; P<0.001). The odds ratio for white-coat hypertensives to develop home hypertension was elevated even in the subgroup with normal home blood pressures (home blood pressure: <125/80 mm Hg; odds ratio: 2.24; P=0.007).² These results indicate that white-coat hypertension could pose a greater risk for the development of home hypertension, independent of home blood pressure levels at baseline. Therefore, we were interested in the results from the subgroup analysis of the home blood pressure levels or ambulatory blood pressure levels at baseline in the Pressioni Arteriose Monitorate e Loro Associazioni Study.

The results from the Pressioni Arteriose Monitorate e Loro Associazioni Study confirm the findings from the Ohasama Study. We also reported that, although stroke risk in white-coat hypertensives did not significantly differ from that in normotensives, on the basis of ambulatory blood pressure . . . [Full Text of this Article]

This article has been cited by other articles:

				G. Mancia, M. Bombelli, R. Facchetti, F. Madotto, F. Quarti-Trevano, H. P. Friz, G. Grassi, and R. Sega Response to Long-Term Risk in Subjects With White-Coat Hypertension Hypertension, November 1, 2009; 54(5): e134 - e134. [Full Text] [PDF]