This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Smith, P. G. Articles by Mills, E. Search for Related Content PubMed PubMed Citation Articles by Smith, P. G. Articles by Mills, E. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Medline Plus Health Information High Blood Pressure Seniors' Health Hazardous Substances DB METHOXAMINE HYDROCHLORIDE TYRAMINE

Hypertension, Vol 6, 54-60, Copyright © 1984 by American Heart Association

ARTICLES

Ontogeny of neural and non-neural contributions to arterial blood pressure in spontaneously hypertensive rats

PG Smith, CW Poston and E Mills

Arterial blood pressure was measured directly by cannulation in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats on postnatal Days 1, 5, 9, 20, 42, and 82-86. The time course for development of the following variables was established: resting diastolic and basal (after ganglionic blockade) pressure, the neural contribution to resting pressure (resting minus basal pressure), vascular reactivity to a noradrenergic agonist, methoxamine, and to endogenous sympathetic nerve terminal norepinephrine released by tyramine (maximum pressor response and ED50) and resting and basal heart rate. Resting diastolic pressure was higher in SHR compared to WKY by 24 hours after birth. In both strains, the increase in resting diastolic pressure with age was interrupted by a plateau period (Days 5- 9 in SHR; Days 9-20 in WKY). Juxtaposition of the development curves was such that the interstrain differences in pressure were statistically significant in all periods studied except Days 5 and 9. Both basal and neurally mediated components of resting diastolic blood pressure were elevated in SHR compared to WKY. The magnitude of the interstrain difference in basal pressure remained constant during development while the magnitude of the neurally mediated component showed accelerated development through 42 days of age. Reactivity to methoxamine and tyramine was higher in SHR, but the magnitude of the difference did not change with age. Cardiac sympathetic tone was higher in SHR than WKY, but did not account for the increased resting diastolic pressure in SHR.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				M. S. Blumberg, T. G. Knoot, and R. F. Kirby Neural and hormonal control of arterial pressure during cold exposure in unanesthetized week-old rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1514 - R1521. [Abstract] [Full Text] [PDF]

				J. Zicha and J. Kunes Ontogenetic Aspects of Hypertension Development: Analysis in the Rat Physiol Rev, October 1, 1999; 79(4): 1227 - 1282. [Abstract] [Full Text] [PDF]

				W. P. Robertson and G. G. Schofield Primary and adaptive changes of A-type K+ currents in sympathetic neurons from hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1758 - R1765. [Abstract] [Full Text] [PDF]

				R. F. Kirby, G. Sokoloff, E. Perdomo, and M. S. Blumberg Thermoregulatory and Cardiac Responses of Infant Spontaneously Hypertensive and Wistar-Kyoto Rats to Cold Exposure Hypertension, June 1, 1999; 33(6): 1465 - 1469. [Abstract] [Full Text] [PDF]

				S. A. Everson, G. A. Kaplan, D. E. Goldberg, and J. T. Salonen Anticipatory Blood Pressure Response to Exercise Predicts Future High Blood Pressure in Middle-aged Men Hypertension, May 1, 1996; 27(5): 1059 - 1064. [Abstract] [Full Text]