Hypertension, Vol 6, 654-659, Copyright © 1984 by American Heart Association
ND Vlachakis, F Ransom, E Kogosov, E Woodcock, N Alexander and RF Maronde
The activity of the sympathetic nervous system, as measured by levels of
plasma and cardiac catecholamines and catecholamine metabolites and the
function of cardiac alpha- and beta-adrenergic receptors, was evaluated at
3 days and 4 weeks after induction of one-kidney, one clip hypertension
(1K1C) in the rat. At 3 days, the plasma level of norepinephrine (NE) was
lower in the 1K1C group than the control group (p less than 0.01), whereas
epinephrine (E) and the metabolites dihydroxymandelic acid (DOMA),
dihydroxyphenylglycol (DOPEG), and normetanephrine (NMN) were similar in
both groups. In addition, cardiac content of catecholamines, their
metabolites, and adrenergic receptors were similar in both groups. At 4
weeks, plasma levels of NE and DOPEG were lower (p less than 0.01), whereas
levels of DOMA and NMN were higher (p less than 0.02 and p less than 0.001,
respectively) in the 1K1C group than the control group. Cardiac content of
NE (p less than 0.01), and DOPEG (p less than 0.05) was significantly
lower, whereas DOMA and NMN were significantly higher (p less than 0.01) in
the 1K1C group as compared to controls. In addition, cardiac density of
both alpha- and beta-adrenergic receptors was reduced in the 1K1C group,
whereas receptor affinities were unchanged.(ABSTRACT TRUNCATED AT 250
WORDS)
ARTICLES
Sympathetic activity and cardiac adrenergic receptors in one-kidney, one clip hypertension in rats