This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hunt, S. C. Articles by Ash, K. O. Search for Related Content PubMed PubMed Citation Articles by Hunt, S. C. Articles by Ash, K. O.

Hypertension, Vol 8, 30-36, Copyright © 1986 by American Heart Association

ARTICLES

Associations of three erythrocyte cation transport systems with plasma lipids in Utah subjects

SC Hunt, RR Williams, JB Smith and KO Ash

To investigate the pathophysiology of essential hypertension, detailed biochemical and clinical variables were collected and analyzed for 2091 Utah subjects aged 3 to 83 years. Three different measurements of erythrocyte cation transport were obtained: Na+-Li+ countertransport, Li+-K+ cotransport, and furosemide-insensitive Li+ efflux into MgCl2. Total plasma cholesterol, triglycerides, and high density lipoprotein cholesterol levels were obtained from fasting subjects. Levels of high density lipoprotein subfractions 2 and 3 were also obtained from 350 subjects. Standardized data collection also included blood pressure, height, weight, and presence or absence of a diagnosis or treatment of essential hypertension. In univariate analyses of all 1420 adults, each of the three transport systems showed the same significant correlations with triglyceride levels (r = 0.33-0.35, p less than 0.0001), high density lipoprotein concentration (r = -0.19 to -0.21, p less than 0.001), and weight (r = 0.22-0.28, p less than 0.0001). In multivariate regression analyses, values for each transport system were significantly higher in hypertensive subjects; values for triglycerides, high density lipoprotein, and usually, the high density lipoprotein subfractions continued to have strong significant independent associations with all three transport systems; and weight remained significantly related only to Na+-Li+ countertransport. In separate logistic regressions, plasma triglyceride levels (positively, p less than 0.001) and high density lipoprotein subfraction 3 levels (inversely, p less than 0.03) were associated with hypertension itself. In multivariate analyses among 671 children, high density lipoprotein and high density lipoprotein subfraction 3 levels showed significant (p less than 0.05) inverse correlations with Na+-Li+ countertransport and furosemide-insensitive Li+ efflux.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				C. G. Savopoulos, A. I. Hatzitolios, N. A. Katsiki, M. Baltatzi, M. Kosmidou, N. Raikos, D. P. Mikhailidis, A. G. Ziakas, G. Kaiafa, and N. Tsesmeli Sodium-Lithium Countertransport Activity in Healthy, Dyslipidemic, and Hypertensive Individuals Angiology, January 1, 2009; 59(6): 727 - 735. [Abstract] [PDF]

				A. B. Weder, M. C. Delgado, X. Zhu, L. Gleiberman, D. Kan, and A. Chakravarti Erythrocyte Sodium-Lithium Countertransport and Blood Pressure: A Genome-Wide Linkage Study Hypertension, March 1, 2003; 41(3): 842 - 846. [Abstract] [Full Text] [PDF]

				N. J. Schork, J. P. Gardner, L. Zhang, D. Fallin, B. Thiel, H. Jakubowski, and A. Aviv Genomic Association/Linkage of Sodium Lithium Countertransport in CEPH Pedigrees Hypertension, November 1, 2002; 40(5): 619 - 628. [Abstract] [Full Text] [PDF]

				P. Mead, R. Wilkinson, and T. H. Thomas Thiol Protein Defect in Sodium-Lithium Countertransport in Subset of Essential Hypertension Hypertension, December 1, 1999; 34(6): 1275 - 1280. [Abstract] [Full Text] [PDF]

				J. Zicha, Z. Dobesova, and J. Kunes Plasma Triglycerides and Red Cell Ion Transport Alterations in Genetically Hypertensive Rats Hypertension, September 1, 1997; 30(3): 636 - 640. [Abstract] [Full Text]

				M. Laurenzi, M. Cirillo, W. Panarelli, M. Trevisan, R. Stamler, A. R. Dyer, and J. Stamler Baseline Sodium-Lithium Countertransport and 6-Year Incidence of Hypertension: The Gubbio Population Study Circulation, February 4, 1997; 95(3): 581 - 587. [Abstract] [Full Text]

				Y. Chi, D. M. de Freitas, M. Sikora, and V. K. Bansal Correlations of Na+-Li+ Exchange Activity With Na+ and Li+ Binding and Phospholipid Composition in Erythrocyte Membranes of White Hypertensive and Normotensive Individuals : A Nuclear Magnetic Resonance Investigation Hypertension, March 1, 1996; 27(3): 456 - 464. [Abstract] [Full Text]

				O. Giampietro, E. Matteucci, G. Catapano, G. Dell'Omo, L. Talarico, C. Di Muro, V. Di Bello, and R. Pedrinelli Microalbuminuria and Erythrocyte Sodium-Hydrogen Exchange in Essential Hypertension Hypertension, May 1, 1995; 25(5): 981 - 985. [Abstract] [Full Text]

				D. M. Cummings, P. Amadio Jr, L. Nelson, and J. M. Fitzgerald The Role of Calcium Channel Blockers in the Treatment of Essential Hypertension Arch Intern Med, February 1, 1991; 151(2): 250 - 259. [Abstract] [PDF]

				R. R. Williams, S. C. Hunt, P. N. Hopkins, B. M. Stults, L. L. Wu, S. J. Hasstedt, G. K. Barlow, S. H. Stephenson, J.-M. Lalouel, and H. Kuida Familial Dyslipidemic Hypertension: Evidence From 58 Utah Families for a Syndrome Present in Approximately 12% of Patients With Essential Hypertension JAMA, June 24, 1988; 259(24): 3579 - 3586. [Abstract] [PDF]