Hypertension, Vol 8, 133-141, Copyright © 1986 by American Heart Association
JP Koepke and GF DiBona
The role of central nervous system alpha-adrenergic and beta-adrenergic
receptors in the increased renal sympathetic nerve activity and
antinatriuresis resulting from environmental stress (air stress) in
conscious spontaneously hypertensive rats (SHR) was examined.
Intracerebroventricular administration of the alpha 2-adrenergic receptor
agonist clonidine (1, 5, and 15 micrograms) prevented the effects of air
stress on renal sympathetic nerve activity and urinary sodium excretion.
Clonidine, 5 and 15 micrograms, lowered baseline mean arterial pressure and
renal sympathetic nerve activity and increased baseline urine flow rate and
urinary sodium excretion; clonidine, 1 micrograms, had no effect on these
baseline levels. Intravenous administration of 5 micrograms, but not 1
microgram of clonidine, abolished the renal responses to air stress.
Intracerebroventricular administration of alpha 2-adrenergic receptor
antagonists (yohimbine, rauwolscine) reversed the effects of clonidine,
alpha 2-adrenergic receptor blockade alone, alpha 1-adrenergic receptor
blockade (20 micrograms prazosin), or combined alpha 1-adrenergic and alpha
2- adrenergic receptor blockade (30 micrograms phenoxybenzamine) had no
effect on the renal sympathetic nerve activity or antinatriuretic responses
to air stress. Intracerebroventricular, but not intravenous, administration
of the beta 2-adrenergic receptor antagonist ICI 118551 (30 micrograms)
prevented the increased renal sympathetic nerve activity and
antinatriuretic responses to air stress. In contrast,
intracerebroventricular administration of the beta 1-adrenergic receptor
antagonist atenolol (30 micrograms) had no effect on the renal responses to
air stress. These results indicate that the increased renal sympathetic
nerve activity and antinatriuresis resulting from environmental stress in
conscious SHR can be prevented by pharmacological stimulation of central
alpha 2-adrenergic receptors or by blockade of central beta 2-adrenergic
receptors.
ARTICLES
Central adrenergic receptor control of renal function in conscious hypertensive rats
This article has been cited by other articles:
 |
|
 |
|
  M. A. Burmeister, M. A. Ansonoff, J. E. Pintar, and D. R. Kapusta Nociceptin/Orphanin FQ (N/OFQ)-Evoked Bradycardia, Hypotension, and Diuresis Are Absent in N/OFQ Peptide (NOP) Receptor Knockout Mice J. Pharmacol. Exp. Ther., September 1, 2008; 326(3): 897 - 904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Snyder, S. T. Turner, M. J. Joyner, J. H. Eisenach, and B. D. Johnson The Arg16Gly polymorphism of the {beta}2-adrenergic receptor and the natriuretic response to rapid saline infusion in humans J. Physiol., August 1, 2006; 574(3): 947 - 954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zheng, W. G. Mayhan, K. R. Bidasee, and K. P. Patel Blunted nitric oxide-mediated inhibition of sympathetic nerve activity within the paraventricular nucleus in diabetic rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R992 - R1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Snyder, K. C. Beck, N. M. Dietz, J. H. Eisenach, M. J. Joyner, S. T. Turner, and B. D. Johnson Arg16Gly polymorphism of the {beta}2-adrenergic receptor is associated with differences in cardiovascular function at rest and during exercise in humans J. Physiol., February 15, 2006; 571(1): 121 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Head and S. L. Burke Sympathetic Responses to Stress and Rilmenidine in 2K1C Rabbits: Evidence of Enhanced Nonvascular Effector Mechanism Hypertension, March 1, 2004; 43(3): 636 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tank, A. Diedrich, C. Schroeder, M. Stoffels, G. Franke, A. M. Sharma, F. C. Luft, and J. Jordan Limited Effect of Systemic {beta}-Blockade on Sympathetic Outflow Hypertension, December 1, 2001; 38(6): 1377 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Menegaz, D. R. Kapusta, H. Mauad, and A. de Melo Cabral Activation of {alpha}2-receptors in the rostral ventrolateral medulla evokes natriuresis by a renal nerve mechanism Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R98 - R107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Kapusta and V. A. Kenigs Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1999; 277(4): R987 - R995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Kapusta, J.-K. Chang, and V. A. Kenigs Central Administration of [Phe1Psi (CH2-NH)Gly2]Nociceptin(1-13)-NH2 and Orphanin FQ/Nociceptin (OFQ/N) Produce Similar Cardiovascular and Renal Responses in Conscious Rats J. Pharmacol. Exp. Ther., April 1, 1999; 289(1): 173 - 180. [Abstract] [Full Text]
|
|
|
|
|
|
A. D. M. Cabral, D. R. Kapusta, V. A. Kenigs, and K. J. Varner Central alpha 2-receptor mechanisms contribute to enhanced renal responses during ketamine-xylazine anesthesia Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1998; 275(6): R1867 - R1874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sanchez-Palacios, S. Y. Jones, and G. F. Dibona Role of angiotensin in renal sympathetic activation in nephrotic syndrome Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R808 - R813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. DiBona, S. Y. Jones, and L. L. Sawin Renal Sympathetic Neural Mechanisms as Intermediate Phenotype in Spontaneously Hypertensive Rats Hypertension, March 1, 1996; 27(3): 626 - 630. [Abstract] [Full Text]
|
|
|
|
|
|
G. F. DiBona and S. Y. Jones Analysis of Renal Sympathetic Nerve Responses to Stress Hypertension, April 1, 1995; 25(4): 531 - 538. [Abstract] [Full Text]
|
|