This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bing, R. F. Articles by Swales, J. D. Search for Related Content PubMed PubMed Citation Articles by Bing, R. F. Articles by Swales, J. D.

Hypertension, Vol 8, 483-488, Copyright © 1986 by American Heart Association

ARTICLES

Leukocyte ionized calcium and sodium content and blood pressure in humans

RF Bing, AM Heagerty, JA Jackson, H Thurston and JD Swales

The relationship between leukocyte ionized calcium concentration, sodium content, and blood pressure was studied in normotensive subjects with (n = 17) and without (n = 21) a family history of hypertension and in untreated patients with essential hypertension (n = 22). There was a highly significant correlation between intracellular ionized calcium and mean supine blood pressure (measured on the same occasion) in normal subjects with no family history of hypertension (r = +0.73, p less than 0.01). This relationship was lost in normal subjects with a family history of hypertension, and in hypertensive patients there was a nonsignificant negative correlation between intracellular ionized calcium and blood pressure (r = +0.08 and -0.31, respectively). Intracellular ionized calcium was similar in the normotensive groups (both, 126 +/- 7 nmol/L) and slightly but nonsignificantly elevated in hypertensive patients (143 +/- 10 nmol/L; p = 0.09). There was no correlation between intracellular ionized calcium and sodium content in any group (r less than 0.1). These results indicate that while leukocyte ionized calcium in normotensive subjects with no family history of hypertension may reflect smooth muscle contractility resulting in the positive correlation between leukocyte ionized calcium and blood pressure, this relationship is lost in hypertensive patients and subjects predisposed to hypertension. This may be due to an altered relationship between leukocyte and smooth muscle calcium handling in these subjects or to non-calcium-mediated influences on blood pressure.

This article has been cited by other articles:

				P. T. Delva, C. Pastori, M. Degan, G. D. Montesi, and A. Lechi Intralymphocyte Free Magnesium in a Group of Subjects With Essential Hypertension Hypertension, September 1, 1996; 28(3): 433 - 439. [Abstract] [Full Text]

				I. Saito, E. Takeshita, T. Saruta, S. Nagano, and T. Sekihara Blood Pressure Response to a Calcium Entry Blocker in Normotensive Subjects With or Without a Family History of Hypertension Angiology, December 1, 1987; 38(12): 883 - 888. [Abstract] [PDF]