Hypertension, Vol 9, 157-163, Copyright © 1987 by American Heart Association
TF Luscher, L Raij and PM Vanhoutte
Experiments were designed to study endothelium-dependent responses in
salt-sensitive (DS) and salt-resistant Dahl rats (DR). The rats were fed a
low sodium (0.1% NaCl) or high sodium (8% NaCl) diet for 8 weeks. Blood
pressure in DS fed a high sodium diet was higher than that in the remaining
animals. Aortic rings with and without endothelium were suspended for
isometric tension recording. Acetylcholine, adenosine 5'- diphosphate, and
thrombin induced endothelium-dependent relaxations that were significantly
depressed in the aorta of DS fed a high sodium diet. The relaxations in
response to sodium nitroprusside were only slightly, but significantly,
depressed in DS fed a high sodium diet. Removal of the endothelium greatly
enhanced the response to serotonin and norepinephrine. In rings with, but
not without, endothelium taken from rats fed a high sodium diet, the
tension developed in response to serotonin and norepinephrine was
significantly greater than that in animals fed a low sodium diet. These
experiments indicate that endothelium-dependent relaxations to
acetylcholine, adenosine 5'- diphosphate, and thrombin are depressed in
hypertensive Dahl rats; this effect probably reflects a decreased release
of endothelium-derived relaxing factor(s), although structural changes
might contribute; and the responsiveness to vasoconstrictor agents is
increased in DS and DR fed a high sodium diet. These findings may indicate
differential effects of blood pressure and dietary salt on endothelial
function.
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Endothelium-dependent vascular responses in normotensive and hypertensive Dahl rats
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