Hypertension, Vol 9, 245-252, Copyright © 1987 by American Heart Association
H Urata, Y Tanabe, A Kiyonaga, M Ikeda, H Tanaka, M Shindo and K Arakawa
After a general clinical observation period of over 4 weeks, 20 essential
hypertensive subjects (Japanese) were randomly divided into two groups. One
group (n = 10; 4 men and 6 women; 51.4 +/- 2.8 years of age) agreed to
physical training using bicycle ergometer exercise with the intensity at
blood lactate threshold for 60 minutes three times a week for 10 weeks,
while the other group (n = 10; 4 men and 6 women; 51.0 +/- 2.9 years of
age) did no particular physical training and was followed once a week as
the control. Changes in blood pressure, hemodynamics, and humoral factors
of the exercised group were compared with values in the controls. The
following significant changes were found only in the exercised group. Blood
pressure was significantly (p less than 0.01) reduced. Whole blood and
plasma volume indices were significantly reduced (p less than 0.05, p less
than 0.01, respectively). The change in ratio of serum sodium to potassium
positively correlated with the change in systolic blood pressure (r = 0.76,
p less than 0.02). Plasma norepinephrine concentrations both at rest and at
the workload of blood lactate threshold during graded exercise tests were
significantly reduced (p less than 0.05, p less than 0.02 respectively)
after 10 weeks of exercise training. The change in the resting level of
plasma norepinephrine positively correlated with that in the mean blood
pressure. No such changes were observed in the control group. In both
groups, body weight and urinary sodium excretion showed no statistically
significant changes.(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
Antihypertensive and volume-depleting effects of mild exercise on essential hypertension
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