on February 16, 2009
Published online before print February 16, 2009, doi: 10.1161/HYPERTENSIONAHA.108.122002
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Submitted on August 22, 2008
From the Center of Clinical Endocrinology and Gerontology (J.M., S.Z.), Sofia, Bulgaria; Assistance Publique–Hôpitaux de Paris (O.S.), Hôpital Tenon, Service de Médecine Interne, Paris, France; Faculté de Médecine (O.S.), Université Paris et Marie Curie Paris-6, Paris, France; Assistance Publique–Hôpitaux de Paris (L.A., X.J., P.-F.P.), Hôpital Européen Georges Pompidou, Unité d'Hypertension Artérielle, Paris, France; and the Faculté de Médecine (L.A., X.J., P.-F.P.), Université Paris Descartes, Paris, France. * To whom correspondence should be addressed. E-mail: olivier.steichen{at}tnn.aphp.fr.
Abstract—An association between primary aldosteronism and metabolism disorders has been reported. The aim of this retrospective study was to test for this association by comparison between large cohorts of patients with primary aldosteronism and with essential hypertension. We retrieved the records of 460 cases with primary aldosteronism (103 lateralized, 150 not lateralized, and 207 undetermined) and of 1363 controls with essential hypertension individually matched for age and sex. We compared clinical history; blood pressure levels; body mass index; levels of fasting plasma glucose and serum triglycerides; total, high-density lipoprotein, and low-density lipoprotein cholesterol; and the prevalence of diabetes mellitus and impaired fasting glucose among subtypes of primary aldosteronism, as well as between cases with primary aldosteronism and their matched controls. Fasting plasma glucose and serum lipid levels did not differ among the 3 subtypes of primary aldosteronism. The prevalence of impaired fasting glucose was lower in patients with primary aldosteronism than their matched controls, but the prevalence of hyperglycemia (impaired fasting glucose or diabetes mellitus) and blood levels of glucose and lipids did not differ between cases and controls. There was no significant difference between preoperative and postoperative levels of either fasting plasma glucose or serum lipids in patients who underwent adrenalectomy and had follow-up data available. The analysis of this large group of patients with primary aldosteronism and essential hypertension does not confirm a higher prevalence of carbohydrate or lipid metabolism disorders in the former. It is unlikely that the prevalence of metabolic syndrome differs significantly between patients with primary aldosteronism and those with essential hypertension.
Revised on September 12, 2008
Fasting Plasma Glucose and Serum Lipids in Patients With Primary Aldosteronism. A Controlled Cross-Sectional Study
Joanna Matrozova;
Key words: diabetes mellitus • hyperaldosteronism • primary • hyperlipidemia • hypertension, essential
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