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Original Article

Captopril inhibits endothelin-1 secretion from endothelial cells through bradykinin.

N Momose, K Fukuo, S Morimoto, T Ogihara
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https://doi.org/10.1161/01.HYP.21.6.921
Hypertension. 1993;21:921-924
Originally published June 1, 1993
N Momose
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K Fukuo
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S Morimoto
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T Ogihara
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Abstract

Incubation with captopril, an angiotensin I converting enzyme inhibitor, for 24 hours at concentrations up to 10(-7) M inhibited endothelin-1 secretion by endothelial cells. This inhibition of endothelin-1 secretion was reversed by coincubation with 3 x 10(-3) M NG-nitro-L-arginine, an inhibitor of nitric oxide synthesis. Furthermore, captopril enhanced the production of nitric oxide in endothelial cells, suggesting that enhancement of nitric oxide production participates in captopril-induced inhibition of endothelin-1 secretion. Moreover, in the presence of 10(-6) M D-Arg,[Hyp3,Thi5,8,D-Phe7]-bradykinin, a bradykinin B2 receptor antagonist, captopril did not inhibit but rather stimulated endothelin-1 secretion, whereas bradykinin inhibited endothelin-1 secretion, and this inhibition by bradykinin was reversed by coincubation with NG-nitro-L-arginine. In addition, enhancement of nitric oxide production induced by either captopril or bradykinin was inhibited by D-Arg,[Hyp3,Thi5,8,D-Phe7]-bradykinin. Although 10(-6) M des-Arg9-[Leu8]-bradykinin, a bradykinin B1 receptor antagonist, did not affect nitric oxide production by bradykinin, it enhanced the inhibition of endothelin-1 secretion by bradykinin. Furthermore, 10(-7) M des-Arg9-bradykinin, a bradykinin B1 receptor agonist, stimulated endothelin-1 secretion by endothelial cells. These findings suggest that angiotensin I converting enzyme inhibitor inhibits endothelin-1 secretion by the accumulation of endogenous bradykinin in endothelial cells and that the inhibition of endothelin-1 secretion by bradykinin is mediated via B2 receptors.

  • Copyright © 1993 by American Heart Association
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Hypertension
June 1993, Volume 21, Issue 6 Pt 2
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    Captopril inhibits endothelin-1 secretion from endothelial cells through bradykinin.
    N Momose, K Fukuo, S Morimoto and T Ogihara
    Hypertension. 1993;21:921-924, originally published June 1, 1993
    https://doi.org/10.1161/01.HYP.21.6.921

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    Captopril inhibits endothelin-1 secretion from endothelial cells through bradykinin.
    N Momose, K Fukuo, S Morimoto and T Ogihara
    Hypertension. 1993;21:921-924, originally published June 1, 1993
    https://doi.org/10.1161/01.HYP.21.6.921
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