Skip to main content
  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

  • Home
  • About this Journal
    • General Statistics
    • Editorial Board
    • Editors
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
    • Acknowledgment of Reviewers
    • Clinical Implications
    • Clinical-Pathological Conferences
    • Controversies in Hypertension
    • Editors' Picks
    • Guidelines Debate
    • Meeting Abstracts
    • Recent Advances in Hypertension
    • SPRINT Trial: the Conversation Continues
  • Resources
    • Instructions to Reviewers
    • Instructions for Authors
    • →Article Types
    • → Submission Guidelines
      • Research Guidelines
        • Minimum Information About Microarray Data Experiments (MIAME)
      • Abstract
      • Acknowledgments
      • Clinical Implications (Only by invitation)
      • Conflict(s) of Interest/Disclosure(s) Statement
      • Figure Legends
      • Figures
      • Novelty and Significance: 1) What Is New, 2) What Is Relevant?
      • References
      • Sources of Funding
      • Tables
      • Text
      • Title Page
      • Online/Data Supplement
    • →Tips for Easier Manuscript Submission
    • → General Instructions for Revised Manuscripts
      • Change of Authorship Form
    • → Costs to Authors
    • → Open Access, Repositories, & Author Rights Q&A
    • Permissions to Reprint Figures and Tables
    • Journal Policies
    • Scientific Councils
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
  • Facebook
  • Twitter

  • My alerts
  • Sign In
  • Join

  • Advanced search

Header Publisher Menu

  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

Hypertension

  • My alerts
  • Sign In
  • Join

  • Facebook
  • Twitter
  • Home
  • About this Journal
    • General Statistics
    • Editorial Board
    • Editors
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
    • Acknowledgment of Reviewers
    • Clinical Implications
    • Clinical-Pathological Conferences
    • Controversies in Hypertension
    • Editors' Picks
    • Guidelines Debate
    • Meeting Abstracts
    • Recent Advances in Hypertension
    • SPRINT Trial: the Conversation Continues
  • Resources
    • Instructions to Reviewers
    • Instructions for Authors
    • →Article Types
    • → Submission Guidelines
    • →Tips for Easier Manuscript Submission
    • → General Instructions for Revised Manuscripts
    • → Costs to Authors
    • → Open Access, Repositories, & Author Rights Q&A
    • Permissions to Reprint Figures and Tables
    • Journal Policies
    • Scientific Councils
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
Articles

Prognostic Significance of the White Coat Effect

Paolo Verdecchia, Giuseppe Schillaci, Claudia Borgioni, Antonella Ciucci, Carlo Porcellati
https://doi.org/10.1161/01.HYP.29.6.1218
Hypertension. 1997;29:1218-1224
Originally published June 1, 1997
Paolo Verdecchia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Giuseppe Schillaci
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Claudia Borgioni
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Antonella Ciucci
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carlo Porcellati
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Tables
  • Info & Metrics
  • eLetters

Jump to

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Tables
  • Info & Metrics
  • eLetters
Loading

Abstract

Abstract The difference between clinic and ambulatory blood pressure (BP) has been used to quantify the pressure reactivity to the doctor’s visit (white coat effect). We investigated the prognostic significance of the clinic-ambulatory BP difference in the setting of the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA) study. A total of 1522 subjects contributed 6371 person-years of observation. All subjects had an initial off-therapy diagnostic workup including 24-hour noninvasive ambulatory BP monitoring. The predicted values of ambulatory BP progressively diverged from the identity line (white coat effect of 0 mm Hg) with increasing clinic BP, but the predicted values of clinic BP tended toward the identity line with increasing ambulatory BP. Hence, the clinic-ambulatory BP difference showed a direct association with clinic BP and an inverse association with ambulatory BP. Consequently, a high clinic-ambulatory BP difference predicted both a high clinic and a low ambulatory BP, whereas a low clinic-ambulatory BP difference predicted both a low clinic and a high ambulatory BP. The clinic-ambulatory BP difference showed also a direct association with age. During up to 9 years of follow-up (mean, 4.2 years), there were 157 major cardiovascular morbid events (125 nonfatal and 32 fatal). The rate of total cardiovascular morbid events did not differ (log-rank test) among the four quartiles of the distribution of the clinic-ambulatory BP difference (2.13, 2.92, 2.10, and 2.83 events per 100 patient-years for systolic BP and 2.94, 2.14, 2.58, and 2.16 events per 100 patient-years for diastolic BP). Also, the rate of fatal cardiovascular events did not differ among the four quartiles of the distribution of the clinic-ambulatory BP difference. The clinic-ambulatory BP difference, taken as a measure of the white coat effect, does not predict cardiovascular morbidity and mortality in subjects with essential hypertension.

  • prognosis
  • blood pressure monitoring, ambulatory
  • hypertension, white coat

Measurement of blood pressure (BP) by the doctor in the clinic environment may trigger an alerting reaction, leading to a transient pressor rise in the patient.1 2 The BP rise is maximal during the first 4 minutes of the visit and persists over about 10 minutes.3 4 A reliable measurement of the transient pressor rise during the visit, usually referred to as the white coat effect or phenomenon, is possible through intra-arterial or noninvasive techniques that allow a beat-by-beat estimate of the BP rise from immediately before to during the visit. The white coat effect has also been estimated by the difference between clinic BP and average daytime ambulatory BP,5 6 on the assumption that average daytime ambulatory BP reflects the BP immediately before the visit. However, Parati et al7 recently demonstrated that there is no association between the BP rise from before to during the visit, determined beat-to-beat with the Finapres method, and the difference between clinic and daytime ambulatory BPs. The prognostic significance of the white coat effect is still unsettled, while recent prospective data suggest that isolated clinic hypertension, also referred to as white coat hypertension,8 9 appears to be a condition of low cardiovascular morbidity.10 11 12

In the Progetto Ipertensione Umbria Monitoraggio Ambulatoriale (PIUMA) study,10 13 all subjects underwent baseline off-therapy clinic BP determination and 24-hour noninvasive ambulatory BP monitoring, and all were subsequently followed for up to 9 years for assessment of cardiovascular morbidity and mortality. Thus, we analyzed the PIUMA database to investigate correlates and the prognostic significance of the difference between clinic and ambulatory BPs before treatment, taken as a surrogate measure of the white coat effect.

Methods

Subjects

The study group was composed of 1522 hypertensive subjects (51% men; mean age, 52 years [SD 12]) enrolled in the PIUMA study, a registry of morbidity and mortality in subjects with essential hypertension whose off-therapy initial diagnostic work included 24-hour noninvasive ambulatory BP monitoring according to a standardized protocol.10 13 All subjects had clinic systolic BP of 140 mm Hg or higher and/or diastolic BP of 90 mm Hg or higher on at least three visits at 1-week intervals and fulfilled all the following inclusion criteria: (1) no previous treatment for hypertension or withdrawal from antihypertensive drugs at least 4 weeks before the study; (2) no clinic or laboratory evidence of heart failure, coronary heart disease, valvular defects, or secondary causes of hypertension; and (3) at least one valid BP measurement per hour over the 24 hours. The initial evaluation in the PIUMA study has been described elsewhere.10 13

BP Measurement

Clinic BP was measured by a mercury sphygmomanometer with the subject sitting for at least 10 minutes. Heart rate was determined immediately thereafter. No caffeine ingestion or cigarette smoking was permitted during the previous 2 hours. Ambulatory BP was recorded with ambulatory BP monitors (SpaceLabs 90202 and 90207) set to take a reading every 15 minutes throughout the 24 hours. Normal daily activities were allowed, and subjects were told to keep their nondominant arm still and relaxed to the side during measurements. Daytime and nighttime BP averages were calculated by the so-called narrow fixed-clock intervals (daytime period from 10 am to 8 pm, nighttime period from midnight to 6 am) to avoid the transitional periods (from 6 to 10 am and from 8 pm to midnight) during which a variable number of subjects may be awake or asleep. It has been previously shown that the narrow fixed-clock intervals method is appropriate for estimation of daytime and nighttime BPs14 ; also, in our and others’15 experience, the periods of wakefulness and sleep resulting from subjects’ diaries may not always be accurate. The spontaneous day-to-day variations of 24-hour, daytime, and nighttime ambulatory BPs were previously assessed in some of these subjects.16

Echocardiography

M-mode echocardiographic study of the left ventricle was performed under cross-sectional control with commercially available machines according to standard laboratory procedures described previously.10 13 Only tracings with optimal visualization of interfaces and showing simultaneous visualization of the septum, left ventricular (LV) internal diameter, and posterior wall were considered adequate for determination of LV mass. Echocardiographic examinations were performed by two physicians and tracings read by two other investigators. The mean value from at least five measurements of the left ventricle per observer was computed. At the time of the echocardiographic examination, all involved investigators were unaware of subjects’ casual and ambulatory BP values. LV mass (grams) was determined with the formula of Devereux et al17 —LV Mass=0.80×{1.04×[(Septal Thickness+LV Internal Diame-ter+Posterior Wall Thickness)3−(LV Internal Diameter)3]}+0.6 g—and normalized by body surface area. LV mass was also corrected by height elevated at a power of 2.7, as suggested by de Simone et al.18

Electrocardiography

Standard 12-lead electrocardiograms were recorded on all subjects at 25 mm/s and 1 mV/cm calibration. Tracings were coded and interpreted by two investigators without knowledge of other subject data. Interobserver differences occurred for less than 5% of readings and were resolved by consensus. Subjects with complete bundle branch block, previous myocardial infarction, Wolff-Parkinson-White syndrome, or atrial fibrillation were excluded from the analysis. None of the subjects was being treated with digitalis. LV hypertrophy was diagnosed with the sex-specific Cornell voltage (sum of the amplitudes of S wave in V3 and R wave in aVL >2.0 mV in women and >2.8 mV in men).19

Follow-up

All subjects were followed by their family doctors in cooperation with the out-patient clinic of the referring hospital and treated with the aim of reducing clinic BP below 140/90 mm Hg using standard lifestyle and pharmacological measures. By protocol, therapeutic strategies were based on clinic BP, although ambulatory BP reports remained accessible to subjects and their doctors. Diuretics, β-blockers, angiotensin-converting enzyme inhibitors, calcium channel blockers, and α1-blockers, alone or in various combinations, were the antihypertensive drugs most frequently used. Since no more than 30% of the subjects had the opportunity to repeat 24-hour ambulatory BP monitoring during therapy at a distance of months or years from the initial evaluation, telephone interviews were conducted with most of the subjects to ascertain the incidence of major complications of hypertension. All interviews were conducted directly with the subjects without knowledge of the results of ambulatory BP monitoring.

Hospital record forms and other available original source documents were reviewed in conference by the authors of this study for the subjects who died from any cause or developed a major fatal or nonfatal cardiovascular event. Cardiovascular events included myocardial infarction, stroke, sudden death, angina pectoris, coronary revascularization, transient cerebral ischemic attack, aortoiliac occlusive disease verified at angiography, documented thrombotic occlusion of a retinal artery, progressive heart failure requiring hospitalization, or renal failure requiring dialysis. Transient ischemic attack was defined by the diagnosis, made by a physician, of any sudden focal neurological deficit that cleared completely in less than 24 hours. Heart failure was defined by the simultaneous presence of at least two major criteria or one major plus two minor criteria as suggested in the Framingham Study.20 The international standard criteria used to diagnose cardiovascular events in the PIUMA study have been described elsewhere.10 13

Data Analysis

Parametric data are reported as mean±SD. Standard descriptive and comparative statistical analyses were undertaken. The outcome events studied were fatal plus nonfatal cardiovascular morbid events. Event rate is presented as the number of events per 100 patient-years based on the ratio of the observed number of events to the total number of patient-years of exposure. Survival curves in the four quartiles of the distribution of the difference between clinic and average daytime ambulatory BPs were estimated with the Kaplan-Meier product-limit method21 and compared by the Mantel (log-rank) test.22 In two-tailed tests, values of P<.05 were considered statistically significant. SAS statistical software (version 6.08, SAS Institute) was used to perform the analysis.

Results

Table 1⇓ shows the main descriptive data in the overall population. Overall, 40% of the subjects were grouped in stage I as defined by the Fifth Joint National Committee report on the detection, evaluation, and treatment of high BP (JNC-V) (clinic systolic BP 140 to 159 mm Hg and diastolic BP 90 to 99 mm Hg).23 The prevalence of echocardiographic LV hypertrophy was 25.3% using the threshold value of 125 g/m2 and was 41.3% using the division line of 51 g/height2.7. The prevalence of LV hypertrophy at electrocardiography was 8.9% using the Cornell score.19 The difference between clinic and daytime ambulatory BPs averaged 13.5 mm Hg (SD 15) for systolic pressure and 4.8 mm Hg (SD 9) for diastolic pressure. The limits for definition of the four quartiles of the distribution of the clinic-ambulatory BP difference were 3, 13, and 23 mm Hg for systolic BP and −1, 5, and 11 mm Hg for diastolic BP.

View this table:
  • View inline
  • View popup
Table 1.

Descriptive Data in the Study Population (n=1522)

Table 2⇓ shows the main descriptive data in the four quartiles of the distribution of the clinic-ambulatory BP difference. Age, clinic systolic BP, and the proportion of women progressively increased from the lowest to the highest quartile of the distribution for systolic BP (all comparisons between quartiles, P<.01) but not for diastolic BP. LV mass, the prevalence of LV hypertrophy at electrocardiography, and the prevalence of diabetes did not differ among the four quartiles of the distribution for both systolic and diastolic BPs. The prevalence of smokers progressively decreased from the bottom to the top quartile of the distribution of the clinic-ambulatory BP difference for both systolic and diastolic BPs (all comparisons between quartiles, P<.01).

View this table:
  • View inline
  • View popup
Table 2.

Descriptive Data in the Four Quartiles of the Distribution of Clinic-Ambulatory Blood Pressure Difference

As shown in Fig 1⇓, there was a direct association between clinic BP and average daytime ambulatory systolic (r=.61, P<.001) and diastolic (r=.60, P<.001) BPs. The predicted values of ambulatory systolic and diastolic BPs progressively diverged from the identity line (white coat effect of 0 mm Hg), with the increase in clinic BP over most of its distribution (Average Daytime Systolic BP=62.7+0.52×Clinic Systolic BP; Average Daytime Diastolic BP=30.7+0.63×Clinic Systolic BP). However, the predicted values of clinic systolic and diastolic BPs tended toward the identity line, with the increase in ambulatory BP over most of its distribution (Clinic Systolic BP=53.3+0.73×Average Daytime Systolic BP; Clinic Diastolic BP=44.8+0.57×Average Daytime Diastolic BP). Consequently, as shown in Table 3⇓ and Fig 2⇓, the clinic-ambulatory BP difference showed a direct association with clinic BP and an inverse association with ambulatory BP. The clinic-ambulatory systolic BP difference showed also a direct association with age (r=.32, P<.01). Table 4⇓ shows that antihypertensive treatment during follow-up did not differ among the four quartiles of the distribution of the clinic-ambulatory BP difference.

Figure 1.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1.

Association between clinic and average daytime ambulatory blood pressures (BPs). Predicted values of ambulatory BP progressively diverged from the identity line (white coat effect of 0 mm Hg) with the increase in clinic BP (left), but after reversion of the association, the predicted values of clinic BP tended toward the identity line with the increase in ambulatory BP (right).

Figure 2.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 2.

Clinic-ambulatory blood pressure (BP) difference displays a direct association with clinic BP (r=.59 for systolic and r=.40 for diastolic BP) and inverse association with ambulatory BP (r=−.28 for systolic and r=−.50 for diastolic BP).

View this table:
  • View inline
  • View popup
Table 3.

Relation of the Difference Between Clinic and Average Daytime Blood Pressures to Age and Blood Pressure (White Coat Effect)

View this table:
  • View inline
  • View popup
Table 4.

Distribution of Antihypertensive Treatment

Cardiovascular Morbidity

During follow-up, there were 157 major cardiovascular morbid events (32 fatal and 125 nonfatal), and the 1522 study subjects contributed 6371 person-years of observation. There were 12 subjects with fatal stroke, 5 with fatal myocardial infarction, 15 with sudden cardiac death, 37 with nonfatal stroke, 12 with transient ischemic attack, 17 with nonfatal myocardial infarction, 20 with new-onset angina, 4 who underwent coronary surgery, 11 with severe heart failure requiring hospitalization, 15 with new-onset aortoiliac occlusive disease, 2 with occlusion of the retinal artery, and 5 with renal failure requiring dialysis. The rate of events in each quartile of the distribution of the clinic-ambulatory BP difference is reported in Fig 3⇓. The rate of total cardiovascular morbid events did not differ (log-rank test) among the four quartiles of the distribution of the clinic-ambulatory BP difference (2.13, 2.92, 2.10, and 2.83 events per 100 patient-years for systolic BP and 2.94, 2.14, 2.58, and 2.16 events per 100 patient-years for diastolic BP). Also, the rate of fatal cardiovascular events did not differ among the four quartiles of the distribution of the clinic-ambulatory BP difference (0.38, 0.69, 0.67, and 0.31 events per 100 patient-years for systolic BP and 0.69, 0.36, 0.61, and 0.30 events per 100 patient-years for diastolic BP).

Figure 3.
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 3.

Rate of total (top) and fatal (bottom) cardiovascular morbid events over a follow-up period of 0 to 9.7 years in 1522 subjects with essential hypertension. Cardiovascular morbidity and mortality rates did not differ among the four quartiles of the distribution of the difference between clinic blood pressure and average daytime ambulatory blood pressure.

Discussion

The white coat effect and white coat hypertension differ in their definitions, pathophysiological mechanisms, and clinical significance. The former is a measure of BP change from before to during the visit,3 4 which increases with clinic BP6 24 and age.25 The latter is an attempt to define a low-risk stratum of clinically hypertensive subjects with normal BP levels out of the medical setting,8 26 regardless of their rise in BP from before to during the visit. The white coat effect has been estimated beat-to-beat using invasive3 4 or noninvasive7 techniques, as well as from the difference between clinic BP and average ambulatory BP during the awake period.6 25 27 The definition of white coat hypertension is not yet unanimously settled, requiring consensus on what are “normal” and “abnormal” BP values out of the doctor’s office.5

It is tempting to consider the white coat effect and white coat hypertension as nearly synonymous because a marked rise in BP from before to during the visit suggests an increased likelihood of clinic hypertension associated with normal BP levels outside the medical setting. However, such practice is incorrect for several reasons. First, the white coat effect does not necessarily show an inverse association with the severity of hypertension. In fact, although the magnitude of the white coat effect is greater, on average, in subjects with white coat hypertension than it is in those with higher levels of ambulatory BP (“ambulatory hypertension”),24 it also increases with the severity of clinic hypertension according to JNC-V stage. In contrast, the prevalence of white coat hypertension decreases with increasing JNC-V stage.24 In other words, a small white coat effect may lead to white coat hypertension in subjects with mild hypertension and mildly increased ambulatory BP, whereas a large white coat effect may still be associated with increased ambulatory BP levels in subjects with moderate or severe hypertension and high levels of ambulatory BP. Second, there is less target-organ damage in subjects with white coat hypertension than in those with ambulatory hypertension, although it is unrelated to the magnitude of the white coat effect. In some studies,24 27 28 but not in all,29 no association has been found between the magnitude of the white coat effect and a widely used measure of target-organ damage, such as LV mass, which in most studies,9 24 30 31 32 but not in all,33 34 35 was normal in individuals with white coat hypertension. Third, the estimate of the white coat effect from the difference between clinic and awake ambulatory BPs may not reflect the true increase in BP elicited by the clinic visit. Parati et al7 did not detect any association between the white coat effect determined beat-to-beat from before to during the visit and the difference between clinic and daytime ambulatory BPs.

The present study is the first to address the prognostic significance of the clinic-ambulatory BP difference in a large cohort of subjects with essential hypertension, who contributed 6371 person-years of observation. The rate of total and fatal cardiovascular events over an observation period of up to 9 years did not show any association with the white coat effect. Since cardiovascular morbidity and mortality are directly associated with clinic BP and initial prospective data show that this seems to the case for ambulatory BP,5 10 12 36 the opposite sign of the relation of the clinic-ambulatory BP difference to clinic BP versus ambulatory BP may provide a potential explanation for the lack of prognostic significance of this surrogate measure of the white coat effect. Such an opposite relation appears to be a mathematical consequence of the fact that the predicted values of daytime ambulatory BP diverged from the identity line with the rise in clinic BP, whereas the predicted values of clinic BP tended toward the identity line with the increase of ambulatory BP (Fig 1⇑). Consequently, a high clinic-ambulatory BP difference was associated not only with high values of clinic BP, which would imply a detrimental prognostic effect, but also with low values of ambulatory BP, which would imply a favorable prognostic effect (Fig 2⇑). On the other hand, a low difference between clinic and ambulatory BPs was associated with both a low clinic BP and a high ambulatory BP.

In this study, we found an inverse association between the white coat effect and cigarette smoking since the prevalence of smokers progressively decreased from the bottom to the top quartile of the distribution of the white coat effect. Cigarette smoking evokes a persistent rise in ambulatory BP in hypertensive subjects,37 38 39 and through this mechanism, it may be associated with a lesser clinic-ambulatory BP difference for any given value of clinic BP.

The prevalence of women progressively increased from the bottom to the top quartile of the clinic-ambulatory BP difference, and this finding may reflect a higher BP reactivity to clinic visits in women. Female sex is an established independent predictor of white coat hypertension.8

In conclusion, our prospective findings show that the clinic-ambulatory BP difference, taken as a measure of the white coat effect, does not predict cardiovascular morbidity and mortality in subjects with essential hypertension.

Acknowledgments

This work was supported in part by grants from Associatione Umbria Cuore e Ipertensione, Perugia, Italy.

Footnotes

  • Reprint requests to Dr Paolo Verdecchia, Ospedale Generale Regionale “R. Silvestrini,” Area Omogenea di Cardiologia e Medicina, Località San Sisto, 06156 Perugia PG, Italy.

  • Received October 28, 1996.
  • Revision received November 14, 1996.
  • Accepted December 13, 1996.

References

  1. ↵
    Riva Rocci S. La tecnica della sfigmomanometria. Gazzetta Medica di Torino. 1897;10:181-191.
    OpenUrl
  2. ↵
    Ayman D, Goldshine AD. Blood pressure determinations by patients with essential hypertension: the difference between clinic and home readings before treatment. Am J Med Sci. 1940;200:465-474.
    OpenUrlCrossRef
  3. ↵
    Mancia G, Bertinieri G, Grassi G, Parati G, Pomidossi G, Ferrari A, Gregorini L, Zanchetti A. Effects of blood pressure measured by the doctor on patient’s blood pressure and heart rate. Lancet. 1983;2:695-698.
    OpenUrlCrossRefPubMed
  4. ↵
    Mancia G, Parati G, Pomidossi G, Grassi G, Casadei R, Zanchetti A. Alerting reaction and rise in blood pressure during measurement by physician and nurse. Hypertension. 1987;9:209-215.
    OpenUrlAbstract/FREE Full Text
  5. ↵
    Pickering TG. The ninth Sir George Pickering memorial lecture: ambulatory monitoring and the definition of hypertension. J Hypertens. 1992;10:401-409.
    OpenUrlCrossRefPubMed
  6. ↵
    Pickering TG. Blood pressure measurement and detection of hypertension. Lancet. 1994;344:31-35.
    OpenUrlCrossRefPubMed
  7. ↵
    Parati G, Ulian L, Santucciu C, Omboni S, Zanchetti A, Mancia G. The difference between clinic and ambulatory blood pressure is not a measure of the white-coat effect. J Hypertens. 1996;14(suppl 1):S262. Abstract.
  8. ↵
    Pickering TG, James GD, Boddie C, Harshfield GA, Blank S, Laragh JH. How common is white-coat hypertension? JAMA. 1988;259:225-228.
    OpenUrlCrossRefPubMed
  9. ↵
    White WB, Schulman P, McCabe EJ, Dey HM. Average daily blood pressure, not office pressure, determines cardiac function in patients with hypertension. JAMA. 1989;261:873-877.
    OpenUrlCrossRefPubMed
  10. ↵
    Verdecchia P, Porcellati C, Schillaci G, Borgioni C, Ciucci A, Battistelli M, Guerrieri M, Gatteschi C, Zampi I, Santucci A, Santucci C, Reboldi G. Ambulatory blood pressure: an independent predictor of prognosis in essential hypertension. Hypertension. 1994;24:793-801.
    OpenUrlAbstract/FREE Full Text
  11. ↵
    Pickering TG. Clinic measurement of blood pressure and white-coat hypertension. In: Pickering TG, ed. Ambulatory Monitoring and Blood Pressure Variability. London, UK: Science Press Ltd; 1991:7.1-7.14.
  12. ↵
    Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Porcellati C. White-coat hypertension. Lancet. 1996;348:1444-1445.
    OpenUrlPubMed
  13. ↵
    Verdecchia P, Schillaci G, Gatteschi C, Zampi I, Battistelli M, Bartoccini C, Porcellati C. Blunted nocturnal fall in blood pressure in hypertensive women with future cardiovascular morbid events. Circulation. 1993;88:986-992.
    OpenUrlAbstract/FREE Full Text
  14. ↵
    Fagard R, Brguljan J, Thijs L, Staessen J. Prediction of the actual awake and asleep blood pressures by various methods of 24 h pressure analysis. J Hypertens. 1996;14:557-563.
    OpenUrlCrossRefPubMed
  15. ↵
    Harshfield GA. How should circadian blood pressure variation be determined? Am J Hypertens. 1996;9:97. Letter.
  16. ↵
    Verdecchia P, Schillaci G, Boldrini F, Guerrieri M, Zampi I, Porcellati C. Quantitative assessment of day-to-day spontaneous variability in non-invasive ambulatory blood pressure measurements in essential hypertension. J Hypertens. 1991;9(suppl 6):S322-S323.
  17. ↵
    Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57:450-458.
    OpenUrlCrossRefPubMed
  18. ↵
    De Simone G, Daniels SR, Devereux RB, Meyer RA, Roman MJ, de Divitiis O, Alderman MH. Left ventricular mass and body size in normotensive children and adults: assessment of allometric relations and of the impact of overweight. J Am Coll Cardiol. 1992;20:1251-1260.
    OpenUrlCrossRefPubMed
  19. ↵
    Casale PN, Devereux RB, Kligfield P, Eisenberg RR, Miller DH, Chaudhary BS, Phillips MC. Electrocardiographic detection of left ventricular hypertrophy: development and prospective validation of improved criteria. J Am Coll Cardiol. 1985;6:572-580.
    OpenUrlPubMed
  20. ↵
    McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure. N Engl J Med. 1971;285:1441-1446.
  21. ↵
    Kaplan ER, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
    OpenUrlCrossRef
  22. ↵
    Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep. 1966;50:163-170.
    OpenUrlPubMed
  23. ↵
    Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure. The 1992 Report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure (JNC V). Arch Intern Med. 1993;153:154-183.
    OpenUrlCrossRefPubMed
  24. ↵
    Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Zampi I, Gattobigio R, Sacchi N, Porcellati C. White-coat hypertension and white-coat effect: similarities and differences. Am J Hypertens. 1995;8:790-798.
    OpenUrlAbstract/FREE Full Text
  25. ↵
    Mansoor GA, McCabe EJ, White WB. Determinants of the white-coat effect in hypertensive subjects. J Hum Hypertens. 1996;10:87-92.
    OpenUrlPubMed
  26. ↵
    Pickering TG. White-coat hypertension. Curr Opin Nephrol Hypertens. 1996;5:192-198.
    OpenUrlCrossRefPubMed
  27. ↵
    Gosse P, Promax H, Durandet P, Clementy J. ‘White-coat hypertension’: no harm for the heart. Hypertension. 1993;22:766-770.
    OpenUrlAbstract/FREE Full Text
  28. ↵
    Schillaci G, Verdecchia P, Boldrini F, Vignai E, Benemio G, Guerrieri M, Comparato E, Porcellati C. Irrilevanza della pressione arteriosa clinica, rispetto a quella ambulatoriale, nella definizione del rischio di ipertrofia ventricolare sinistra nell’ipertensione arteriosa essenziale. G Ital Cardiol. 1991;21:651-659.
    OpenUrlPubMed
  29. ↵
    Penzo M, Guzzardi G, Palatini P. Relazione tra reazione d’allarme alla misurazione pressoria e complicanze ipertensive. Cardiologia. 1995;40:117-122.
    OpenUrlPubMed
  30. ↵
    Verdecchia P, Schillaci G, Boldrini F, Zampi I, Porcellati C. Variability between current definitions of ‘normal’ ambulatory blood pressure: implications in the assessment of white-coat hypertension. Hypertension. 1992;20:555-562.
    OpenUrlAbstract/FREE Full Text
  31. ↵
    Cavallini MC, Roman MJ, Pickering TG, Schwartz JE, Pini R, Devereux RB. Is white-coat hypertension associated with arterial disease or left ventricular hypertrophy? Hypertension. 1995;26:413-419.
    OpenUrlAbstract/FREE Full Text
  32. ↵
    Pierdomenico SD, Lapenna D, Guglielmi MD, Antidormi T, Schiavone C, Cuccurullo F, Mezzetti A. Target organ status and serum lipids in patients with white coat hypertension. Hypertension. 1995;26:801-807.
    OpenUrlAbstract/FREE Full Text
  33. ↵
    Cardillo C, De Felice F, Campia U, Folli G. Psychophysiological reactivity and cardiac end-organ changes in white coat hypertension. Hypertension. 1993;21:836-844.
    OpenUrlPubMed
  34. ↵
    Kuwajima I, Suzuki Y, Fujisawa A, Kuramoto K. Is white coat hypertension innocent? Structure and function of the heart in the elderly. Hypertension. 1993;22:826-831.
    OpenUrlAbstract/FREE Full Text
  35. ↵
    Cerasola G, Cottone S, Nardi E, D’Ignoto G, Volpe V, Mulè G, Carollo C. White-coat hypertension and cardiovascular risk. J Cardiovasc Risk. 1995;2:545-549.
    OpenUrlCrossRefPubMed
  36. ↵
    Perloff D, Sokolow M, Cowan R. The prognostic value of ambulatory blood pressure. JAMA. 1983;249:2792-2798.
    OpenUrlCrossRefPubMed
  37. ↵
    Mann SJ, James GD, Wang RS, Pickering TG. Elevation of ambulatory systolic blood pressure in hypertensive smokers: a case-control study. JAMA. 1991;265:2226-2228.
    OpenUrlCrossRefPubMed
  38. ↵
    Asmar RG, Girerd XJ, Brahimi M, Safavian A, Safar ME. Ambulatory blood pressure measurement, smoking and abnormalities of glucose and lipid metabolism in essential hypertension. J Hypertens. 1992;10:181-187.
    OpenUrlCrossRefPubMed
  39. ↵
    Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Zampi I, Battistelli M, Gattobigio R, Sacchi N, Porcellati C. Cigarette smoking, ambulatory blood pressure and cardiac hypertrophy in essential hypertension. J Hypertens. 1995;13:1209-1215.
    OpenUrlCrossRefPubMed
View Abstract
Back to top
Previous ArticleNext Article

This Issue

Hypertension
June 1997, Volume 29, Issue 6
  • Table of Contents
Previous ArticleNext Article

Jump to

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Tables
  • Info & Metrics
  • eLetters

Article Tools

  • Print
  • Citation Tools
    Prognostic Significance of the White Coat Effect
    Paolo Verdecchia, Giuseppe Schillaci, Claudia Borgioni, Antonella Ciucci and Carlo Porcellati
    Hypertension. 1997;29:1218-1224, originally published June 1, 1997
    https://doi.org/10.1161/01.HYP.29.6.1218

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
  •  Download Powerpoint
  • Article Alerts
    Log in to Email Alerts with your email address.
  • Save to my folders

Share this Article

  • Email

    Thank you for your interest in spreading the word on Hypertension.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Prognostic Significance of the White Coat Effect
    (Your Name) has sent you a message from Hypertension
    (Your Name) thought you would like to see the Hypertension web site.
  • Share on Social Media
    Prognostic Significance of the White Coat Effect
    Paolo Verdecchia, Giuseppe Schillaci, Claudia Borgioni, Antonella Ciucci and Carlo Porcellati
    Hypertension. 1997;29:1218-1224, originally published June 1, 1997
    https://doi.org/10.1161/01.HYP.29.6.1218
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Related Articles

Cited By...

Hypertension

  • About Hypertension
  • Instructions for Authors
  • AHA CME
  • Guidelines and Statements
  • Permissions
  • Journal Policies
  • Email Alerts
  • Open Access Information
  • AHA Journals RSS
  • AHA Newsroom

Editorial Office Address:
7272 Greenville Ave.
Dallas, TX 75231
email: hypertension@heart.org

Information for:
  • Advertisers
  • Subscribers
  • Subscriber Help
  • Institutions / Librarians
  • Institutional Subscriptions FAQ
  • International Users
American Heart Association Learn and Live
National Center
7272 Greenville Ave.
Dallas, TX 75231

Customer Service

  • 1-800-AHA-USA-1
  • 1-800-242-8721
  • Local Info
  • Contact Us

About Us

Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The need for our work is beyond question. Find Out More about the American Heart Association

  • Careers
  • SHOP
  • Latest Heart and Stroke News
  • AHA/ASA Media Newsroom

Our Sites

  • American Heart Association
  • American Stroke Association
  • For Professionals
  • More Sites

Take Action

  • Advocate
  • Donate
  • Planned Giving
  • Volunteer

Online Communities

  • AFib Support
  • Garden Community
  • Patient Support Network
  • Professional Online Network

Follow Us:

  • Follow Circulation on Twitter
  • Visit Circulation on Facebook
  • Follow Circulation on Google Plus
  • Follow Circulation on Instagram
  • Follow Circulation on Pinterest
  • Follow Circulation on YouTube
  • Rss Feeds
  • Privacy Policy
  • Copyright
  • Ethics Policy
  • Conflict of Interest Policy
  • Linking Policy
  • Diversity
  • Careers

©2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a qualified 501(c)(3) tax-exempt organization.
*Red Dress™ DHHS, Go Red™ AHA; National Wear Red Day ® is a registered trademark.

  • PUTTING PATIENTS FIRST National Health Council Standards of Excellence Certification Program
  • BBB Accredited Charity
  • Comodo Secured