Association Between TGF-β Gene Polymorphism and Left Ventricular Hypertrophy in Essential Hypertension

Abstract

P61

The aim of the study was to evaluate the possible association between two TGF-β1 gene polymorphisms and left ventricular hypertrophy in a group of essential hypertensive patients (EH). Ninety-three non treated EH underwent 24-hour ambulatory blood pressure, two-dimensional guided M-mode echocardiography in order to measure left ventricular mass index (LVMI), and TGF-β1 Leu¹⁰/Pro and Arg²⁵/Pro polymorphism genotyping. As shown in the table, 24-h SBP and DBP were significantly higher in homozygous patients for the Arg²⁵ allele of the TGF-β1 gene. Likewise, homozygous patients for the Leu¹⁰ allele and homozygous patients for the Arg²⁵ allele of the TGF-β1 gene had significanlty higher LVMI. We conclude that these TGF-β1 gene polymorphisms are associated with the severity of blood pressure and left ventricular hypertrophy in EH patients.