Response to Polycystic Ovary Syndrome: Androgens, Autonomic Nervous System, and Hypertension
We thank Dr Perciaccante1 and his colleague for their interest and insightful comments on our recent article2 regarding the association between the characteristic hyperandrogenemia and the elevated systolic and diastolic blood pressure in young women with polycystic ovary syndrome.
Perciaccante et al propose that the cardiovascular autonomic nervous system might be affected directly by androgen levels or by hyperandrogenemia-induced insulin resistance and might, therefore, act as a possible link between androgen and blood pressure in women with polycystic ovary syndrome. We agree entirely that the mechanisms underlying hyperandrogenemia and elevated blood pressure are complex, and impaired autonomic nervous system might be a possible reason to explain this association.
However, further investigation and controlled studies are still necessary to substantiate this hypothesis.
Sources of Funding
This study was supported by grants NSC94-2314-B002-195 and NSC95-2314-B002-035 from the National Science Council of Taiwan.
Perciaccante A, Fiorentini A, Valente R, Tubani L. Polycystic ovary syndrome: androgens, autonomic nervous system, and hypertension. Hypertension. 2007: 50: e7.
Chen M-J, Yang W-S, Yang J-H, Chen C-L, Ho H-N, Yang Y-S. Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome. Hypertension. 2007: 49: 1442–1447.