Response to Resistin, Glomerular Filtration Rate, and Insulin Resistance
Yasuharu et al1 found an inverse association between plasma resistin and estimated glomerular filtration rate in a community-based cohort of Japanese individuals, findings that are consistent with our report.2 Furthermore, they observed plasma resistin to be a significant determinant of the homeostasis model assessment of insulin resistance, independent of estimated glomerular filtration rate. We also noted plasma resistin to be correlated with the homeostasis model assessment of insulin resistance after adjustment for age in blacks (ρ=0.11; P=0.002), as well as in whites (ρ=0.09; P=0.027). However, after adjustment for age, sex, estimated glomerular filtration rate, and body mass index, plasma resistin was not significantly associated with the homeostasis model assessment of insulin resistance in either ethnic group (β±SE=0.05±0.06, P=0.44 in blacks and β±SE=−0.08±0.05, P=0.096 in whites). Although some previous studies3,4 have reported an association between resistin and insulin resistance, others5 have not been able to demonstrate any such association. Therefore, the finding by Yasuharu et al1 that, in subjects without chronic kidney diseases, plasma resistin reflects insulin resistance status independent of renal function needs further confirmation.
Sources of Funding
This work was supported by grants HL-81331 and M01 RR00585 from the National Institutes of Health.
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