Response to High-Normal Blood Pressure and Cognition: Supplying the Missing Data

We thank Elias et al¹ for their interest in our work and for providing additional study results supporting our finding that high-normal blood pressure is associated with poor cognitive performance. The data set used by them for this reanalysis is powerful, because it includes a large number of participants with systolic blood pressures values in the high reference range. The convergence of these findings from studies in different countries and in participants with different cultural backgrounds strengthens the insight that high-normal blood pressure is related to cognitive impairment. It should further encourage future studies to analyze whether antihypertensive treatment already in individuals with high-normal systolic blood pressure can slow down cognitive decline.