Response to Aortic Pulse Wave Velocity May Have Prognostic Value Not Just for Hypertension but Also for Abdominal Aortic Aneurysms
We thank Paraskevas et al1 for their comments. The main finding of our study was that pulse wave velocity was consistently related to age and blood pressure but not to other cardiovascular risk factors, such as total cholesterol, low-density or high-density lipoprotein cholesterol, triglycerides, smoking, or body mass index. Only a few studies have examined associations with measures of structural change in the arterial wall, and we did not include these in our review. However, we agree that such changes are likely to be important determinants of pulse wave velocity. Potential structural changes have been reviewed by Zieman et al,2 but there is relatively little information about such changes in humans. Calcification of the arterial wall has recently been shown to be associated with increased arterial stiffness in healthy individuals and may be particularly important.3 Additional studies with independent measures of structural change and selective interventions to determine causality will be required to unravel this fascinating area.
Paraskevas KI, Kyriakides ZS, Mikhailidis DP. Aortic pulse wave velocity may have prognostic value not just for hypertension but also for abdominal aortic aneurysms. Hypertension. 2010; 55: e22.
Zieman SJ, Melanovsky V, Kass DA. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arterioscler Thromb Vasc Biol. 2005; 25: 932–943.
McEniery CM, McDonnell BJ, So A, Aitken S, Bolton CE, Munnery M, Hickson SS, Yasmin, Maki-Petaja KM, Cockcroft JR, Dixon AK, Wilkinson IB; Anglo-Cardiff Collaboration Trial Investigators. Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individuals. Hypertension. 2009; 53: 524–531.