2010 Annual Fall Conference and Scientific Session of the American Heart Association Council for High Blood Pressure Research in Association With the Council on the Kidney in Cardiovascular Disease
The American Heart Association (AHA) High Blood Pressure Research Conference is considered to be among the most important and prestigious medical meetings on hypertension in the world, designed as a scientific program that focuses on disseminating information about the most recent advances in hypertension research. This program provides an opportunity for learning, interacting, and networking between scientists, basic and clinical. Over the past few years there has been significant growth in attendance at the meeting, and in 2010 there was a record number of some 750 registrants, from more than 20 countries. The conference was preceded by a 1-day workshop, organized with the help of Dr Fred Luft, titled “New Paradigms in Hypertension Research,” focusing on 4 major themes: (1) receptors, channels, and signaling; (2) the new biology of the renin-angiotensin system; (3) immunity, salt, and hypertension; and (4) therapeutic approaches, beyond antihypertensive drugs. Presentations at the workshop were given by internationally renowned experts from Australia, Germany, Canada, Italy, and the United States. The workshop was closed, and the official meeting opened by Prof Anna Dominiczak, University of Glasgow, who gave a thought-provoking talk called “Genomics, Proteomics, Metabolics, and Personalized Medicine in Hypertension: Where Are We Going?” This was a perfect foundation to the launch of the official 2010 council meeting.
The scientific program of the conference was abstract based and included more than 500 reviewed abstracts presented in oral and poster sessions. In addition, numerous named award lectures were given by the most outstanding investigators in the hypertension community. The objectives of the meeting were certainly met, and by the end of the 1-day workshop and 2.5-day conference attendees should have satisfactorily been able to do the following: (1) understand the genetics involved in the pathogenesis of hypertension and the translation into clinical practice in terms of prevention, diagnosis, and treatment; (2) identify the mechanisms involved in cardiovascular and renal remodeling and available treatments that target these pathways; (3) appreciate the role of the immune system and inflammation in the pathophysiology of hypertension and the effect of available treatments on this system; (4) identify the hormonal and metabolic mechanisms that link hypertension, obesity, and diabetes mellitus; (5) describe the functioning of the renin-angiotensin-aldosterone system and its role in hypertension, cardiovascular disease, and kidney disease; (6) understand the outcomes of recent major trials in hypertension and cardiovascular disease and incorporate new information from these trials into clinical practice; and (7) gain knowledge of new antihypertensive strategies, including renal nerve ablation, baroreceptor stimulation, and antihypertensive vaccines.
Many named lectures and prestigious awards were presented at the annual meeting. The premier award of the Council for High Blood Pressure Research (CHBPR) is the Novartis Award for Hypertension, which is the highest honor in hypertension research given annually by the CHBPR and Novartis. It recognizes outstanding researchers whose investigations have improved treatment and increased understanding of high blood pressure. The recipients of the 2010 Novartis Award were Dr Paul Vanhoutte (director at the Biopharmaceutical Development Centre and head of the Department of Pharmacology at the University of Hong Kong), who gave a presentation titled “When a Good Guy Turns Bad!” and Dr John Oates (T. Thomas F. Frist Sr Prof of Medicine, Prof of Pharmacology, Vanderbilt University Medical Center, Nashville, TN), whose presentation was titled “Thrombotic Cardiovascular Complications of Metabolic Syndrome” (Figure 1).
The Lifetime Achievement Award is named in honor of Dr Irvine Page and Alva Bradley, who played prominent roles in establishing the National Foundation for High Blood Pressure Research in 1945, which subsequently evolved into the CHBPR of the AHA. The 2010 Page-Bradley Lifetime Achievement Award was presented to Theodore Goodfriend, MD (Professor Emeritus, Medicine and Pharmacology, University of Wisconsin-Madison, Madison, WI) in recognition of his outstanding achievements in the field of hypertension and for his service to the CHBPR (Figure 2).
The Harriet Dustan Award recognizes female investigators who have made outstanding contributions in the field of hypertension. The award was established to honor the memory of Dr Harriet Dustan, a superb clinician-scientist who was a tireless worker on behalf of the CHBPR and the AHA. The 2010 award was given to Dr Kathryn Sandberg, director of the Center for the Study of Sex Differences and a professor in the Department of Nephrology and Hypertension, Georgetown University, Washington, DC (Figure 3). Sandberg's laboratory focuses on the molecular mechanisms underlying the sex differences in the incidence and rate of progression of hypertension and associated cardiovascular and renal diseases.
The Harry Goldblatt New Investigator Award recognizes a new independent investigator working in hypertension or cardiovascular research who has significantly contributed to our understanding of the causes of hypertension and related cardiovascular disease. The 3 outstanding finalists for 2010, selected by the awards committee from applicants who submitted abstracts accepted for presentation, were Drs Matthew Zimmerman, Takayuki Matsumoto, and Paras K. Mishra, with Dr Zimmerman being selected as the winner (Figure 4).
The Arthur C. Corcoran Memorial Lecture was established in 1977 in honor of Arthur Curtis Corcoran's early application of clearance methods in hypertensive patients and animals. This prestigious lecture is presented at the annual meeting by a distinguished honoree from the field of hypertension. The 2010 Corcoran Lecture was given by Dr Timothy Reudelhuber, Director of Molecular Biochemistry of Hypertension at the Clinical Research Institute of Montreal, Quebec, Canada (Figure 5).
The Lewis K. Dahl Memorial Lecture was established in 1988 by the CHBPR in honor of Dr Dahl's pioneering work on the relations among salt, the kidney, and hypertension and for establishing a major genetically based experimental model of hypertension (Dahl salt-sensitive rat). The Dahl lecture is presented each year at the annual meeting by a distinguished honoree from the field of hypertension, and this year was presented by Dr Brian Morris, Professor of Molecular Medical Sciences at the University of Sydney, Sydney, Australia (Figure 6).
The Donald Seldin Lecture of the Council on Kidney in Cardiovascular Disease was presented by Dr Thomas Kleyman (Professor of Medicine, Cell Biology, and Physiology, and Chief, Renal-Electrolyte Division, University of Pittsburgh, Pittsburgh, PA). The named lecture, after Dr Donald Seldin, a pioneer and leader in the field of cardiovascular disease as it relates to kidney failure, continues to enhance awareness concerning the rising epidemic of cardiovascular disease and mortality in patients with chronic kidney disease (Figure 7).
The strengths and significant contributions of the members of the CHBPR were further recognized at the annual Scientific Sessions meeting in Washington, where it was announced that 3 of the CHBPR members, Drs David Harrison, Gordon Williams, and Jay Cohn, were recipients of major AHA awards. In addition, the CHBPR acknowledged and thanked Dr Winnie Barouch for her excellent insights and counsel in her capacity as National Heart, Lung, and Blood Institute/National Institutes of Health liaison to the CHBPR. Dr Barouch was wished well on her retirement.
Supporting the next generation of hypertension investigators is a priority of the CHBPR. As such it is with pride that the council continues to actively support many trainees and young scientists to attend the annual CHBPR conference. In 2010, the following were recipients of the new investigator awards sponsored by the CHBPR: Frédérique Yiannikouris, Christopher Pelham, Kathleen Beehner, Luminita Pojoga, Zhiying Shan, Heinrich Lob, Hujing Xia, Xian Cao, Lin Gao, and Phillip Kopf (Figure 8). New investigator awards sponsored by the Trainee Advocacy Council were given to the following individuals: Xiaolong Zhu, Kathirvel Gopalakrishnan, Di Feng, and Christoph Kopp (Figure 9). New investigator awards sponsored by the Council on Kidney in Cardiovascular Disease were awarded to the following individuals: Nithya Mariappan, James Luther, Carmen De Miguel, and Zhengong Guan (Figure 10). In addition to these council-sponsored awards, 2 new trainee awards were given first to Sonja Tesnovic Kljajic, the top trainee recognized by the High Blood Pressure Research Council of Australia (Figure 11), and second to Domagoj Mladinov, who received an award kindly sponsored by the journal Clinical Science (Figure 12).
It is with much pride that the CHBPR recognized the authors, all members of the CHBPR, AHA, of the top articles published in Hypertension in 2010. These included, in the Basic Science category, articles by Ruisheng Liu and by Morag Young; in the Clinical Science category, articles by Eduardo Pimenta and by Richard A. Preston; and in the Population Science category, articles by Ross Feldman and by Alissa R. Caton.
The 64th meeting of the CHBPR was an enormous success. All of the participants were enriched, whether through gaining new personal knowledge and insights in hypertension research, through changes in scientific approaches in the laboratory, or through learning about novel therapeutic strategies in the management of patients with hypertension and associated conditions. The annual meeting provides a dynamic environment for all of those with an interest in hypertension research to share scientific ideas, to discuss interesting clinical cases, to network with colleagues, and to facilitate mentoring for trainees.
The success of the meeting would not have been possible without the superb assistance from the AHA staff, particularly Susan Kunish; the guidance and support from Dr Clinton Webb, (chair of the CHBPR) and Dr Gabby Navar, (past chair of the CHBPR); and the hard work by the program committee and abstract reviewers who spent many hours reviewing abstracts. Thanks and appreciation are expressed to all.
The 65th meeting will take place next year, September 20 to 24, 2011, in Orlando, Florida. This will be a very special meeting, as it will be a joint conference with the Inter-American Society of Hypertension, organized in collaboration with the president of the Inter-American Society of Hypertension, Dr Navar. Together with the incoming program chair, Dr Greg Fink, I look forward to welcoming you to another great meeting of the CHBPR and the Council on the Kidney in Cardiovascular Disease.
From the meeting, there were 84 articles submitted for consideration, and all were subjected to rigorous peer review. Of these, 18 were accepted for publication and represent some of the important research presented at the meeting. Unfortunately, many meritorious articles could not be accepted. Only those that required minor or no revisions could be accepted for publication in this supplemental issue. Dr John Hall, Editor-in-Chief, encourages the submission of articles from the meeting to be considered for publication in a regular issue of Hypertension. The editors express their appreciation to those who reviewed the articles submitted for this special issue of Hypertension. We regret that only a small representative fraction of the many excellent articles submitted could be published in these proceedings.
The present supplemental issue of Hypertension highlights a selection of articles based on abstracts presented at the 64th Annual Fall Conference of the Councils on High Blood Pressure Research and Kidney in Cardiovascular Disease, held in Washington, DC, October 13 to 16, 2010.
- © 2011 American Heart Association, Inc.