Response to Is Pressure Decrease at Peak Hyperemia Attributed to Poiseuille or Bernoulli or Both?
We thank Turner1 for drawing attention to the likely contribution of the Bernoulli effect as contributing, in addition to the resistive pressure loss, to the drop in mean hydrostatic intra-arterial pressure in the upper limb during hyperemia. This does not of course alter the conclusions of our study, that flow-mediated dilation is offset by a flow-induced reduction in transmural pressure.2 Unlike a resistive pressure drop, that attributed to the Bernoulli effect will be evident at the origin of the artery. Thus, it may be particularly important in modulating transmural pressure proximal to vascular beds that are capable of sustaining large increases in flow, such as skeletal muscle and the myocardium. As Green and Thijssen3 point out in the editorial accompanying our article, such changes in transmural pressure may influence endothelial cell phenotype and arterial remodeling.
King's College London
British Heart Foundation Centre
London, United Kingdom
Letters to the Editor will be published, if suitable, as space permits. They should not exceed 1000 words (typed double-spaced) in length and may be subject to editing or abridgment.
- © 2011 American Heart Association, Inc.
- Turner MJ
- Jiang B,
- Seddon M,
- Fok H,
- Donald A,
- Chowienczyk P
- Green DJ,
- Thijssen DH