Abstract 275: Age-related Changes in Cardiometabolic and Inflammation Risk Markers in Male SHR Rats
This study examined age-related cardiometabolic and inflammatory changes in spontaneously hypertensive rats (SHR). Aging (from 14 to 59 weeks) was accompanied by increases in systolic blood pressure (166±4 vs 224±5 mmHg, p<0.05), diastolic blood pressure (87±5 vs 132±3 mmHg, p<0.05) and heart rate (376±8 vs 400±5 bpm, p<0.05) leading to ventricular hypertrophy, assessed as ventricular to body weight ratio (3.45±0.0.5 vs 3.66±0.08, p<0.05). Aging SHR showed proteinuria (22±2 vs 46±8 mg/day, p<0.05), increased plasma alanine aminotransferase (39±1 vs 60±6 U/l, p<0.05), cholesterol (1.4±0.1 vs 2.6±0.1 mmol/l, p<0.05), triglycerides (0.4±0.1 vs 0.9±0.1 mmol/l, p<0.05) and glucose levels (154±7 vs 181±5 mg/dl, p<0.05). High levels of plasma C-reactive protein (276±11 vs 447±7 μg/ml, p<0.05) was observed in aged SHR. A multiplex inflammatory cytokine assays was used to profile expression of 23 inflammatory mediators. The measurement of soluble cytokines and other analytes in plasma revealed eleven inflammatory mediators, including IL-1α, IL-6 and INF-γ, significantly increased in aged SHR. In conclusion, SHR aging is accompanied by hypertension establishment and ventricular remodeling. Age-related changes in SHR correlates with increase of cardiometabolic and inflammation risk markers.
- © 2012 by American Heart Association, Inc.