Abstract 423: Associations Between Improved Fitness and a Marker of Hypertension Associated Neuro Degenerative Disease S 00B
Neurodegenerative diseases such as Alzheimer’s have recently been linked to hypertension (HTN). S100B is a marker of cerebral injury and the progression of neuro-degeneration. Serum levels of S100B are known to be increased after acute brain trauma, with the progression of chronic neuro-degenerative diseases, and even in the presence of HTN. Optimization of aerobic fitness has long been implicated in the treatment and prevention of HTN. However, no study has investigated whether aerobic exercise training (AEXT) has an effect on the prevention of hypertension associated neurodegenerative disease markers such as S100B.
METHODS: 18 participants ages 40-62 were assessed. To be considered for inclusion participants had to be free of any cardiovascular disease, non-smoking and sedentary. After inclusion participants underwent blood draws, blood pressure (BP) measurements, flow mediated dilation (FMD) analysis using Doppler ultrasound and aerobic exercise testing by measuring VO2max. Participants then followed AEXT (3days/week, 65% of VO2max, 40 minutes/day) for 6 months. S100B serum levels were assessed using an ELISA Assay (Milipore, USA).
Results: AEXT did not significantly change serum S100B levels or BP. However, VO2max fitness levels (24.55 ± 1.01 vs. 27.52 ± 1.59 mL/kg/min) and FMD percentage (6.47 ± 0.9 vs. 9.75 ± 1.09 %) increased significantly (p≤0.008 and p≤0.048 respectively). Although there were no significant correlations between S100B and the above variables before and after AEXT, S100B levels were inversely correlated with VO2max after the six months of AEXT (r = -.594, p≤0.009). Also, participants who improved their VO2max level by at least 3ml/kg/min (N=10) had significantly (p≤0.008) lower S100B levels (45.43 ± 11.9 vs. 64.19 ± 14.16 pg/mL) after the completion of AEXT than participants who did not (N=8).
Conclusion: Although AEXT did not lower BP, it did improve endothelial function. Also, people who responded to AEXT, had significantly better S100B levels. Additionally, the fact that S100B was inversely correlated to VO2max, as was the case after AEXT, implicates a potential role for the improvement of aerobic fitness in the prevention of HTN-associated neurodegenerative diseases.
- © 2012 by American Heart Association, Inc.