Abstract 434: The Epidemic of Hypertension Related Disease and Changing Patterns of Leading Causes of Hospitalization in Patients with Comorbid Hypertension Among US Adults Aged 35 and Older
Objective: To examine the longitudinal trend of hospitalization due to hypertension related diseases and patterns of leading causes of hospitalization in those with comorbid hypertension among US adults aged 35 and older.
Method: We used sample data (n=4,598,488 thousand hospitalized cases) from 1980-2007 National Hospital Discharge Surveys to test trends of patients with 1st diagnosis of hypertension (HT) related hospitalization, and any of 2nd to 7th diagnosis of HT, and HT associated with 10 primary causes of hospitalization. Diseases were coded using ICD-9-CM criteria. Age-adjusted rates of disease were calculated using US 2000 standard population. Trends of hospitalization due to HT related disease and associations between primary cause of hospitalized diseases and HT as comorbidity were tested using multivariate logistic regression models.
Results: Crude hospitalization rates due to 1st diagnosis of HT related disease significantly increased from 1.93% (2327295 / 120579000) in 1980 to 2.14% (5091906/237551000) in 2007. The corresponding age-adjusted hospitalization rates were 1.81% in 1980 and 2.17% in 2007 (test for trend, p<0.01). Similarly, age-adjusted rates due to any of 2nd to 7th diagnosis of HT related diseases significantly increased from 1.23% in 1980 to 5.43% in 2007 (test for trend, p<0.001). Multivariate adjusted logistic regression analysis indicates that in 2007, patients who had any of 2nd to 7th diagnosis of HT, and had primary diagnosis of renal disease had the highest significant odds ratio (OR=7.0, 95%CI: 6.70-7.32) for hospitalization, followed by diabetes (3.47, 3.34-3.59), atherosclerosis (3.10, 2.89-3.32), septicemia (2.08, 1.98-2.19), stroke (1.88, 1.83-1.92), CHD (1.85, 1.81-1.90), heart failure (1.16, 1.12-1.20), and pneumonia and influenza (1.21, 1.16-1.25) than those without these primarily diagnosed diseases, respectively.
Conclusion: The study, using a nationally representative dataset, is the first to demonstrate a 28-years trend that hospitalization due to HT related diseases significantly increased from 1980 to 2007 in the US adults. The study further highlights that patients with primary diagnosis of renal disease or diabetes with comorbid HT have emerged as top causes of hospitalization.
- © 2012 by American Heart Association, Inc.