Creatine Kinase and Pressor Response to Orthostatic Tolerance
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To the Editor:
In a recent publication, Okada et al1 reported that elderly blacks have a blunted sympathetic neural responsiveness, but greater pressor response to orthostasis than elderly whites. The authors conclude that elderly blacks had a greater response in total peripheral resistance for a given change in total muscle sympathetic nerve activity during tilting.
The authors suggested that an augmented sympathetic vascular transduction or enhanced nonadrenergic vasoconstrictor mechanisms are involved in this enhanced pressor response.1 In an earlier article, greater orthostatic tolerance …