Response to Intima–Media Thickness in Children—Need for More Parameters
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We appreciate the comments about the approach to the measurement of carotid intima–media thickness (cIMT), which address important aspects about ultrasound image analysis and reproducibility.
According to the Mannheim cIMT consensus statement,1 the use of automatic detection software is preferred, but manual measurements are accepted provided that quality control is assured. As clearly described in the Methods section of our publication,2 either the caliper method or a semiautomatic contour detection software (Syngo, Siemens) was used in this multisite study, and comparison of 74 samples measured with both methods showed excellent concordance.
To validate further the reference values obtained in our cohort and to place them into a broader context, we compared our results with 2 large reference studies in healthy adults. Our …