In the online-only Data Supplement to the Hypertension article by Jennings et al (Jennings BL, George LW, Pingili AK, Khan NS, Estes AM, Fang XR, Gonzalez FJ, Malik KU. Estrogen Metabolism by Cytochrome P450 1B1 Modulates the Hypertensive Effect of Angiotensin II in Female Mice. Hypertension. 2014;64:134–140), a correction was needed.
The dosage information for 2-hydroxyestradiol, 4-hydroxyestradiol, and 2-methoxyestradiol was inadvertently left out. This information has been added on page 2 of the Data Supplement, under “Treatment groups,” to read:
c) 2-Hydroxyestradiol (2-OHE) and 4-OHE - Mice were infused with Ang II as described above. One group was injected i.p., daily with 2-OHE or 4-OHE, (1.5 mg/kg) the major metabolites of estrogen metabolism by CYP1B1 (5, 6). A separate group was injected with vehicle (DMSO, 20 µl).
d) 2-MeE2 - Mice were infused with Ang II as described above. One group of animals was injected i.p. daily with 2-MeOHE, (1.5 mg/kg) the resultant compound of COMT metabolism of 2-OHE (5). A separate group of animals was injected with vehicle (DMSO, 20 µl).
The authors apologize for the error.
This correction has been made to the online-only Data Supplement, which is available at http://hyper.ahajournals.org/lookup/suppl/doi:10.1161/HYPERTENSIONAHA.114.03275/-/DC1.
- © 2014 American Heart Association, Inc.