Abstract 273: Aerobic, Resistance And Combined Exercise Training Across The Lifespan Are Effective In Improving Heart Rate And Blood Pressure Variability In Obese Mice
The aim of this study was to compare the effects of aerobic, resistance and combined exercise training on autonomic parameters in youth obese mice. Female mice (4 weeks) were randomized into: wild type sedentary (WS, n=11), ob/ob sedentary (OS, n=11), ob/ob aerobic trained (OA, n=8) (treadmill,5days/w, 60min/d, during 8 wks), ob/ob resistance trained (OR, n=8) (ladder climb, 5 days/w, during 8 wks) and ob/ob combined trained (OC, n=8) (alternate days of aerobic and resistance exercise) groups. Blood pressure (BP) signals were directly recorded using a data acquisition system. OS group presented higher blood glucose levels (169±8mg/dL) than WS animals (121±6mg/dL). In addition ob/ob trained groups (OA, OR and OC) groups had reduced blood glucose (OA:133±3, OR:155±9 and OC:143±11mg/dL) in comparison with OS group. Systolic, diastolic and mean BP and heart rate were similar among groups. The ob/ob mice showed an decrease in pulse interval variance and RMSSD compared with WS group. The three types of training were effective in increasing these parameters in trained mice compared with ob/ob sedentary mice. The BP variability was similar among groups; however, the low frequency band of BP was higher in the sedentary groups (WS:10±1 and OS:10±1mmHg2) compared to OA (5±1mmHg2) and OR (5±1mmHg2) groups. . The spontaneous baroreflex sensitivity was lower in ob/ob groups compared to WS (3±0.3 ms/mmHg). Furthermore, the OS group showed decrease in this parameter (0.6±0.3 ms/mmHg) compared to OA (1.7±0.2ms/mmHg) and OR groups (2±0.6ms/mmHg). The OA, OR and OC groups were similar in relation to low frequency band of BP and baroreflex sensitivity. Thus, our results suggest that physical training across the lifespan, either aerobic and/or resistance exercise, can be effective in attenuating the autonomic dysfunctions associated with obesity in mice.
Author Disclosures: M. Sartori: None. F. Santos: None. M.B. da Silva: None. K. De Angelis: None. M.C. Irigoyen: None.
- © 2014 by American Heart Association, Inc.