Abstract 427: Carotid Disease in Postmenopausal Women Correlates with Cardiac Hypertrophy and Ageing
Background: The atherosclerotic carotid disease is characterized by thickening of the intima-media of the vascular wall (IMT), which is considered as a reliable predictor of cardiovascular events. The aim of this study was to investigate a relationship between IMT and nonatherosclerotic cardiac and vascular risk factors in postmenopausal women.
Methods: Left and right carotid IMT, plaque score and resistive index (common, external and internal carotid RI), left ventricular (LV) wall thickness and ascending aorta diameter were determined by echography.
Results: Women’s and men’s age was normally distributed with mean(SD) of 71(11) and 68(11), respectively. Left and right carotid IMTs were strongly correlated to each other (Spearman's r = 0.71 in women and 0.89 in men, p < 0.001). Only the right IMT was correlated with the plaque score at both sexes (Spearman's r = 0.36 in women and 0.37 in men, p = 0.01). The carotid resistive indexes had no significant relationship with the C-IMTs. The LV wall thickness and the ascending aorta diameter had a significantly positive correlation with the right IMT in women (Spearman's r = 0.31 and 0.31, p < 0.05) but not in men. The carotid RIs had a significantly positive association with age in both sexes (Spearman's r ranging between 0.30 and 0.56, p < 0.05). However, right IMT, LV thickness and aortic diameter were positively correlated with age only in women (Spearman's r = 0.33, 0.40 and 0.26 respectively, p < 0.05).
Conclusion: These data demonstrate that nonatherosclerotic risk factors are associated with higher IMT in women but not in men. The synergic action of these factors may contribute to a worse carotid deterioration in postmenopausal women.
Author Disclosures: V.L. Pereira Jr.: B. Research Grant (includes principal investigator, collaborator, or consultant and pending grants as well as grants already received); Significant; FAPESP 2013/14724-0. L.F. Franqueiro: None. L.A. Campos: B. Research Grant (includes principal investigator, collaborator, or consultant and pending grants as well as grants already received); Significant; FAPESP 2013/06698-0. O.C. Baltatu: B. Research Grant (includes principal investigator, collaborator, or consultant and pending grants as well as grants already received); Significant; FAPESP 2013/14724-0, CNPq, 301706/2013-1.
- © 2014 by American Heart Association, Inc.