Abstract 435: The Association Between Initial Antihypertensive Prescription Interval And Medication Adherence: A Cohort Study Among 203,259 Patients
Background: Optimal adherence with antihypertensive medications is crucial to prevent hypertension-related complications. This study evaluated whether the interval of initial antihypertensive prescriptions is associated with better medication adherence among hypertensive patients who received their first-ever antihypertensive agent.
Methods: From a validated clinical database of all patients in the public healthcare sector in Hong Kong, we included all patients who were newly prescribed an antihypertensive agent from 2001 to 2005. They were followed-up for 12 months, and optimal adherence was defined as having the Proportion of Days Covered (PDCs) ≥ 0.80. A binary logistic regression analysis was conducted to test the association between initial prescription interval and adherence level in the subsequent 12 months.
Results: From 203,259 eligible patients with an average age of 58.7 years (SD 17.3), the overall adherence rate was 32.4% [65,856/203,259]. The proportions of patients whose initial prescriptions lasted for ≤ 6 days; 7-14 days; 15-28 days and ≥ 29 days were 23.7%, 24.3%, 15.1% and 37.0%, respectively. After controlling for patients’ age, sex, socioeconomic status, service type, antihypertensive drug class, and district of residence, those whose initial prescription was 15-28 days (adjusted odds ratio [AOR]: 1.90, 95% C.I. 1.82-1.99, p<0.001) and ≥ 29 days (AOR=4.13, 95% C.I. 3.96-4.31, p<0.001) were significantly more likely to be adherent than those who were prescribed for ≤ 6 days.
Conclusions: These findings showed that short initial prescription interval was associated with poorer medication adherence, and this practice should be cautious.
Author Disclosures: M.C. Wong: None. W.W. Tam: None. H.H. Wang: None. W. Chan: None. M.W. Kwan: None. C.S. Cheung: None. E.L. Tong: None. N. Cheung: None.
- © 2014 by American Heart Association, Inc.