Abstract 463: Dietary Intake and Arterial Compliance in a Cohort of People with Type 1 and Type 2 Diabetes
Background: Diabetes is associated with a higher risk of cardiovascular disease (CVD) and diet is a modifiable risk factor. However, few studies have examined the association between dietary intake and measures of arterial compliance, a well-established predictor of CVD, in people with diabetes. The aim was to investigate the relationship between dietary intake, augmentation index (AI), and pulse wave velocity (PWV) in a cohort of people with type 1 and type 2 diabetes.
Methods: Participants were adults with type 1 or type 2 diabetes who completed the Dietary Questionnaire for Epidemiological Studies (v2) Food Frequency Questionnaire and had carotid- femoral PWV (n=95) and/or AI (n=110) measured using a SphygmoCor® XCEL (Sydney, Australia). A random spot urine sample was provided and predicted 24 hour urinary sodium excretion was calculated using the Kawasaki equation.
Results: A negative linear relationship was observed between tertile of dairy intake and PWV which persisted after multivariate adjustment (demographic variables and cardiovascular risk factors) (t=-2.4; p=0.019). PWV was 0.9m/s (95% CI 0.2 to 1.7m/s) lower in the highest tertile (>434g/d) compared to the lowest tertile (<260g/d) of dairy consumption (p=0.02 after multivariate adjustment). There was also a negative linear relationship between AI and tertile of fibre intake (t=-2.6; p=0.012) and tertile of potassium intake (t=-2.4; p=0.019), after multivariate adjustment. Predicted 24hr sodium excretion was positively associated with AI (t=2.2; p=0.029) after adjustment. The lowest tertile of sodium excretion (<69mmol/d) was associated with a 4.7% lower AI compared with the high tertile (>90mmol/d) (p=0.02 after multivariate adjustment). It was estimated that a 100mmol increase in sodium excretion would result in an 8.2% increase in AI.
Conclusion: A dietary pattern that is high in dairy, fibre, and potassium and lower in sodium may improve arterial compliance in people with diabetes.
Author Disclosures: K.S. Petersen: None. P.M. Clifton: None. J.B. Keogh: None.
- © 2014 by American Heart Association, Inc.