Abstract 467: A Combination of Metabolic Syndrome Components Increased the Risk of Incident Atrial Fibrillation in a General Urban Cohort: the Suita Study
Background: Atrial fibrillation (AF), the most common chronic arrhythmia, is linked to increased risks of mortality and cardiovascular disease. Few prospective studies have examined the combined effect of metabolic syndrome (Mets) components on the incidence of AF in a general population. We investigated whether combinational Mets components increase the risk of incident AF in an urban Japanese population.
Methods: The 6,659 Suita Study participants (30-84 yrs old) were initially free of AF and prospectively followed up for incident AF. Standard 12-lead ECGs were obtained from all subjects in the supine position. The participants were diagnosed with AF if AF or atrial flutter was present on ECGs obtained during a biannual routine health examination or if AF was indicated as a present illness by questionnaire, medical records, or the registration of one or more cardiovascular disease events during follow-up. The Mets components were defined as follows: higher blood pressure (HBP, systolic/diastolic BP ≥130/85 mmHg or use of antihypertensive medication), hyperglycemia (fasting plasma glucose >100 mg/dL or use of diabetes medication), hypertriglyceridemia (HTG, serum triglyceride >150 mg/dL or use of medication for HTG), lowered HDL cholesterolemia (HDL <40 mg/dL in men and <50 mg/dL in women), and central obesity (waist circumference >85 cm in men and >80 cm in women). The definition of Mets was used for the current international recommendations, which constitutes the presence of any three or more of five components. Cox proportional hazard ratios (HRs) and 95% confidence intervals (CIs) were analyzed after adjusting for age, gender, smoking, drinking, chronic kidney disease, stroke, and heart disease at baseline.
Results: During the 13 years of follow-up, 242 incident AF events occurred. The adjusted HRs (95% CIs) of incident AF for central obesity, HBP, and Mets were 1.39 (1.06-1.82), 1.41 (1.08-1.85), and 1.34 (1.03-1.75), respectively. Compared with the absence of the components, the adjusted HR (95% CIs) of incident AF for subjects with any three components was 1.72 (1.11-2.67).
Conclusion: Mets, central obesity, and HBP are risk factors for incident AF. Appropriate BP and body weight are important for preventing AF in the general population in Japan.
Author Disclosures: Y. Kokubo: None. T. Kobayashi: None. M. Watanbe: None. S. Kamakura: None. K. Kusano: None. K. Kawanishi: None. Y. Miyamoto: None.
- © 2014 by American Heart Association, Inc.