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Poster Session III

Abstract 550: Plasma Angiotensin-(1-12) Level Is Elevated And Correlates With Proteinuria In Patients With Chronic Kidney Diseases

Norihito Moniwa, Masato Furuhashi, Hideaki Yoshida, Hideki Takizawa, Koichi Hasegawa, Yoshinosuke Shimamura, Tomohiro Mita, Takahiro Fuseya, Shutaro Ishimura, Marenao Tanaka, Nobuyuki Ura, Shigemichi Tanaka, Tetsuji Miura
Hypertension. 2014;64:A550
Norihito Moniwa
Dept of Nephrology, Teine Keijinkai Hosp, Sapporo, Japan
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Masato Furuhashi
Dept of Cardiovascular, Renal and Metabolic Medicine, Sapporo Med Univ Sch of Medicine, Sapporo, Japan
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Hideaki Yoshida
Dept of Cardiovascular, Renal and Metabolic Medicine, Sapporo Med Univ Sch of Medicine, Sapporo, Japan
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Hideki Takizawa
Dept of Nephrology, Teine Keijinkai Hosp, Sapporo, Japan
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Koichi Hasegawa
Dept of Nephrology, Teine Keijinkai Hosp, Sapporo, Japan
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Yoshinosuke Shimamura
Dept of Nephrology, Teine Keijinkai Hosp, Sapporo, Japan
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Tomohiro Mita
Dept of Cardiovascular, Renal and Metabolic Medicine, Sapporo Med Univ Sch of Medicine, Sapporo, Japan
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Takahiro Fuseya
Dept of Cardiovascular, Renal and Metabolic Medicine, Sapporo Med Univ Sch of Medicine, Sapporo, Japan
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Shutaro Ishimura
Dept of Cardiovascular, Renal and Metabolic Medicine, Sapporo Med Univ Sch of Medicine, Sapporo, Japan
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Marenao Tanaka
Dept of Cardiovascular, Renal and Metabolic Medicine, Sapporo Med Univ Sch of Medicine, Sapporo, Japan
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Nobuyuki Ura
Sapporo Nishimaruyama Hosp, Sapporo, Japan
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Shigemichi Tanaka
Dept of Cardiology, Teine Keijinkai Hosp, Sapporo, Japan
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Tetsuji Miura
Dept of Cardiovascular, Renal and Metabolic Medicine, Sapporo Med Univ Sch of Medicine, Sapporo, Japan
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Abstract

Angiotensin-(1-12) [Ang-(1-12)], C-terminally extended form of Ang I, is an alternative precursor of Ang II. Although angiotensinogen, a precursor of both Ang I and Ang-(1-12), is reportedly one of markers of kidney disease, little is known about role of Ang-(1-12) in pathological status especially in human. To address this issue, we measured plasma and urinary Ang-(1-12) by enzyme immunoassay in 4 healthy volunteers and 15 patients with biopsy-proven chronic kidney diseases (CKD). CKD group included minor glomerular abnormality (n=3), IgA nephropathy (n=8), minimal change nephritic syndrome (n=4). Ang-(1-12) level was 55-fold higher in urine than in plasma (Figure; 4.12±1.55 vs 0.075±0.006 ng/mL, P<0.05). Neither plasma Ang-(1-12) nor urinary Ang-(1-12) was correlated with blood pressure. Plasma Ang-(1-12) was positively correlated with urinary protein and tended to be negatively correlated with estimated glomerular filtration ratio (eGFR; Figure). Plasma Ang-(1-12) was higher in the CKD group than in the control (Figure; 0.083±0.006 vs 0.045±0.005 ng/mL, P<0.01). On the other hand, urinary Ang-(1-12) was correlated with neither urinary protein nor eGFR. Urinary Ang-(1-12) tended to be higher in the CKD group than in control (4.94±1.9 vs 1.05±0.6 ng/mL, respectively). The present study showed for the first time that plasma Ang-(1-12) level is elevated in patients with CKD and suggests that increased plasma Ang-(1-12) plays a nephropathic role.


Embedded Image
  • Angiotensin-(1-12)
  • chronic kidney disease
  • estimated glomerular filtration ratio
  • Author Disclosures: N. Moniwa: None. M. Furuhashi: None. H. Yoshida: None. H. Takizawa: None. K. Hasegawa: None. Y. Shimamura: None. T. Mita: None. T. Fuseya: None. S. Ishimura: None. M. Tanaka: None. N. Ura: None. S. Tanaka: None. T. Miura: None.

  • © 2014 by American Heart Association, Inc.
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September 2014, Volume 64, Issue Suppl 1
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    Abstract 550: Plasma Angiotensin-(1-12) Level Is Elevated And Correlates With Proteinuria In Patients With Chronic Kidney Diseases
    Norihito Moniwa, Masato Furuhashi, Hideaki Yoshida, Hideki Takizawa, Koichi Hasegawa, Yoshinosuke Shimamura, Tomohiro Mita, Takahiro Fuseya, Shutaro Ishimura, Marenao Tanaka, Nobuyuki Ura, Shigemichi Tanaka and Tetsuji Miura
    Hypertension. 2014;64:A550, originally published February 5, 2015

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    Abstract 550: Plasma Angiotensin-(1-12) Level Is Elevated And Correlates With Proteinuria In Patients With Chronic Kidney Diseases
    Norihito Moniwa, Masato Furuhashi, Hideaki Yoshida, Hideki Takizawa, Koichi Hasegawa, Yoshinosuke Shimamura, Tomohiro Mita, Takahiro Fuseya, Shutaro Ishimura, Marenao Tanaka, Nobuyuki Ura, Shigemichi Tanaka and Tetsuji Miura
    Hypertension. 2014;64:A550, originally published February 5, 2015
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