Abstract 550: Plasma Angiotensin-(1-12) Level Is Elevated And Correlates With Proteinuria In Patients With Chronic Kidney Diseases
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Abstract
Angiotensin-(1-12) [Ang-(1-12)], C-terminally extended form of Ang I, is an alternative precursor of Ang II. Although angiotensinogen, a precursor of both Ang I and Ang-(1-12), is reportedly one of markers of kidney disease, little is known about role of Ang-(1-12) in pathological status especially in human. To address this issue, we measured plasma and urinary Ang-(1-12) by enzyme immunoassay in 4 healthy volunteers and 15 patients with biopsy-proven chronic kidney diseases (CKD). CKD group included minor glomerular abnormality (n=3), IgA nephropathy (n=8), minimal change nephritic syndrome (n=4). Ang-(1-12) level was 55-fold higher in urine than in plasma (Figure; 4.12±1.55 vs 0.075±0.006 ng/mL, P<0.05). Neither plasma Ang-(1-12) nor urinary Ang-(1-12) was correlated with blood pressure. Plasma Ang-(1-12) was positively correlated with urinary protein and tended to be negatively correlated with estimated glomerular filtration ratio (eGFR; Figure). Plasma Ang-(1-12) was higher in the CKD group than in the control (Figure; 0.083±0.006 vs 0.045±0.005 ng/mL, P<0.01). On the other hand, urinary Ang-(1-12) was correlated with neither urinary protein nor eGFR. Urinary Ang-(1-12) tended to be higher in the CKD group than in control (4.94±1.9 vs 1.05±0.6 ng/mL, respectively). The present study showed for the first time that plasma Ang-(1-12) level is elevated in patients with CKD and suggests that increased plasma Ang-(1-12) plays a nephropathic role.

Author Disclosures: N. Moniwa: None. M. Furuhashi: None. H. Yoshida: None. H. Takizawa: None. K. Hasegawa: None. Y. Shimamura: None. T. Mita: None. T. Fuseya: None. S. Ishimura: None. M. Tanaka: None. N. Ura: None. S. Tanaka: None. T. Miura: None.
- © 2014 by American Heart Association, Inc.
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- Abstract 550: Plasma Angiotensin-(1-12) Level Is Elevated And Correlates With Proteinuria In Patients With Chronic Kidney DiseasesNorihito Moniwa, Masato Furuhashi, Hideaki Yoshida, Hideki Takizawa, Koichi Hasegawa, Yoshinosuke Shimamura, Tomohiro Mita, Takahiro Fuseya, Shutaro Ishimura, Marenao Tanaka, Nobuyuki Ura, Shigemichi Tanaka and Tetsuji MiuraHypertension. 2014;64:A550, originally published February 5, 2015
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- Abstract 550: Plasma Angiotensin-(1-12) Level Is Elevated And Correlates With Proteinuria In Patients With Chronic Kidney DiseasesNorihito Moniwa, Masato Furuhashi, Hideaki Yoshida, Hideki Takizawa, Koichi Hasegawa, Yoshinosuke Shimamura, Tomohiro Mita, Takahiro Fuseya, Shutaro Ishimura, Marenao Tanaka, Nobuyuki Ura, Shigemichi Tanaka and Tetsuji MiuraHypertension. 2014;64:A550, originally published February 5, 2015