Abstract 646: The Existence of a Strong Correlation Between Leptin, TNFα Levels and BMI in Morbidly Obese Appalachian Females
Introduction: Although BMI contributes to increased levels of adipokines, such as leptin, and tumor necrosis factor (TNFα) and to a decrease in adiponectin, few studies have examined the association between leptin, TNFα and body mass index (BMI) in Appalachian females.
Methods: A total of 74 subjects from the Appalachian region were examined for the effect of BMI on the levels of leptin, TNFα, and adiponectin. Patients without overt cardiovascular disease were included. Linear regression analysis was used to analyze for changes in the relationship between BMI, leptin, TNFα and adiponectin. Nonlinear regression was used to determine the odds ratio and confidence intervals.
Results: Serum TNFα and leptin levels were significantly increased in subjects with an increased BMI of 45-72 (9.9pg/ml ± 0.56 and 7.7pg/ml ± 0.6 respectively; p<0.05), compared to subjects with a BMI of 20-32. This was paralleled by increased levels of leptin, TNFα and IL-6. IL-6 was elevated in subjects with a BMI of 45-72 (4.83pg/ml ± 0.40; p<0.02). IL-6 was increased to a greater extent than leptin. In contrast, adiponectin levels were decreased (p<0.05) in subjects with a BMI of > 45-72 (6.63ng/ml ± 0.5; p<0.05), compared to subjects with a BMI of 20-32 (14.43ng/ml ± 0.32).
Conclusion: Our study demonstrates for the first time the unique inflammatory biomarkers profile in morbidly obese females, even before diagnosis of coronary disease, highlighting the possible pathogenic potentials and opens the door for potential use of these biomarkers as a prognostic tool and a therapeutic target that can ameliorate obesity induced cardiovascular dysfunction.
Author Disclosures: E. Thompson: None. K. O'Hanlon: None. M. Getty: None. K. Sodhi: None. E. Maher: None. Z. Khitan: None. N.G. Abraham: None. J. Shapiro: None.
- © 2014 by American Heart Association, Inc.