Abstract P007: Hypertension and Myocardial Mechanics in Patients with Hypertrophic Cardiomyopathy
Introduction: Strain abnormalities in patients with Hypertrophic Cardiomyopathy (HCM) is associated with poor prognosis. Our aim was to assess whether the presence of hypertension in HCM altered myocardial mechanics using strain echocardiographic imaging.
Hypothesis: Hypertension is a risk factor for diminished deformation in patients with HCM.
Methods: A retrospective chart review of patients undergoing HCM evaluation at our facility between December 2008 and December 2011 was performed. Patients were divided into subsets based on the presence of hypertension as a documented diagnosis. All patients had comprehensive echocardiographic assessments with strain imaging. Clinical data was extracted from the electronic medical record. Comparisons in strain values were made between both subsets.
Results: A total of 200 patients was assessed. The average age was 56 years (60% male) and 42.5% of the patients had a diagnosis of hypertension. Global longitudinal strain, Mid strain, Basal strain, Anterior, Lateral, Inferior, Inferolateral strain had no relation to the presence of hypertension. Septal strain (mean without hypertension -14.306 vs with hypertension -16.071, p value: .0069) Inferoseptal strain (mean without hypertension -12.813 vs with hypertension -15, p value: .0018), and Anteroseptal deformation (mean without hypertension -15.301 vs with hypertension -16.784, p value: .0445) however, was increased in patients with hypertension compared to patients with no history of hypertension (See Table)
Conclusions: The presence of hypertension is associated with septal strain abnormalities. Thus, future exploration of hypertension control and hypertrophic cardiomyopathy prognosis and outcomes need to be explored.
Author Disclosures: K.K. Manocha: None. D.F. Snipelisky: None.
- © 2015 by American Heart Association, Inc.