Abstract P049: Relationship between Serum Ghrelin levels and Primary Hypertension: A Meta Analysis
Background: Ghrelin is a novel gut derived peptide hormone suggested to play a role in the etiopathogenesis of Primary Hypertension (HTN). It is hypothesized that ghrelin regulates arterial blood pressure via modulation of central sympathetic activity and peripheral nitric oxide dependent vasodilatory mechanisms. The aim of the present study is to conduct a meta-analysis to evaluate the relationship between serum ghrelin levels and HTN.
Methods: We searched MEDLINE, CINHAL and COCHRANE databases for studies reporting serum ghrelin levels in the HTN and non HTN study population. We included case controls, cohort and cross-sectional studies. We calculated the weighted standardized mean difference (SMD) in serum ghrelin levels between the HTN and control groups.
Results: Our search strategy yielded 309 articles and we included 8 studies enrolling 1659 participants. The median age of the HTN group was 52 yrs. (IQR 47-56) compared to 49 yrs.(IQR 39-54) in the control group. The median body mass index in the HTN group was 28 kg/m2 (IQR 27-34) compared to 25 kg/m2 (IQR 23-27) in the control group. The median percentage of female population in the HTN group was 48 % (IQR 37-61) compared to 51 %(IQR 32-57) in the control group. The unweighted median serum ghrelin levels in the HTN group were 733 pg/ml (IQR 571-5607) compared to 857 pg/ml (IQR 592-7387) in the control group. The SMD of serum ghrelin level was -1.381 (95% CI -2.089,-0.673) p<0.001 comparing those in the HTN group and control group.
Conclusion: Serum ghrelin levels are significantly and negatively associated with HTN. Further studies are needed to address potential confounding factors and confirm this association.
Author Disclosures: P. Agasthi: None. S. Aloor: None. A. Chenna: None. S.R. Chinta: None. A. Onwuanyi: None.
- © 2015 by American Heart Association, Inc.