Abstract P050: Association Between Circulating Selenium Levels and Primary Hypertension: A Meta-analysis
Background: Increasing evidence support the role of oxidative stress in the development of Primary hypertension (HTN). Selenium is an essential micronutrient with antioxidant properties mediated via selenoenzymes like glutathione peroxidases. It is hypothesized that selenium plays a role in blood pressure regulation and HTN prevention. We conducted a meta-analysis to evaluate the relationship between circulating selenium levels and HTN.
Methods: We searched MEDLINE, CINAHL and COCHRANE databases for studies reporting serum selenium levels in the patients with HTN and healthy controls. We calculated the weighted standardized mean difference (SMD) in the serum selenium levels between the HTN and control groups.
Results: Our search strategy yielded 313 articles and we included 10 studies enrolling 10420 participants. The median age of the HTN group was 57 yrs. (IQR 56-58) compared to 46 yrs. (IQR 42-50) in the control group. The median body mass index (BMI) in the HTN group was 28 kg/m2 (IQR 26-29) compared to 25 kg/m2 (IQR 25-27) in the control group. The median percentage of female population in the HTN group was 51 % (IQR 46-53) compared to 51 % (IQR 51-54) in the control group. The unweighted median serum selenium levels in the HTN group were 88 μg/l (IQR 83-113) compared to 95 μg/l (IQR 86-128) in the control group. The SMD of serum selenium level was -1.52 (95% CI -2.36, -0.67) P<0.001 comparing those in the HTN group and control group.
Conclusion: Serum selenium levels are significantly and inversely associated with HTN and this association was not explained by age, sex or BMI. Further studies are needed to confirm this association by adjusting for potential confounders.
Author Disclosures: P. Agasthi: None. S. Aloor: None. V. Yarlagadda: None. A. Chenna: None. A. Onwuanyi: None.
- © 2015 by American Heart Association, Inc.