Abstract P079: Impact of Combined Exercise Training in an Experimental Model of Hypertension Associated With Menopause
In this study we tested the hypothesis that the cardiovascular autonomic dysfunction plays an important role on the management of inflammation and oxidative stress, and that these dysfunctions may in turn be modulated by combined exercise training in an experimental model of hypertension and menopause. Female rats were divided into (n=7/group): control (C) and hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing combined (aerobic+resistance) training (THO). We observed an additional increase in HO group (176±4 mmHg) in relation to H group (165±3 mmHg). However, the THO group (155±3 mmHg) showed a reduction of arterial pressure associated with resting bradycardia. The HO group (50.78±4.61 mmHg2) presented an additional impairment in systolic arterial pressure variability when compared to C and H groups (23.69±0.45 and 34.09±2.37 mmHg2); this dysfunction was not observed in THO group (30.09±2.03 mmHg2). Additionally, an attenuation on vascular sympathetic modulation and an improvement in baroreflex sensitivity were found in the THO when compared to HO group. There was an increase in TNF-α in sedentary hypertensive groups (H and HO vs. C), which was not observed in THO group. Ovariectomy induced an additional increase in cardiac and renal oxidative stress, which were reduced in THO group. The THO group presented an increase in total antioxidant capacity when compared to the other groups. In conclusion, combined exercise training was able to reduce AP associated with improvement on cardiovascular autonomic control, probably reducing cardiac and renal inflammation and oxidative stress, in an experimental model of hypertension and menopause.
Author Disclosures: G. Shimojo: None. D. Dias: None. C. Malfitano: None. I. Sanches: None. M. Irigoyen: None. K. De Angelis: None.
- © 2015 by American Heart Association, Inc.