Abstract P093: The Sflt-1/plgf Ratio Associates with Prolongation of Pregnancy
Objective: To evaluate whether a single determination of the serum sFlt-1/PlGF ratio associates with pregnancy prolongation in women with suspected or confirmed preeclampsia (PE).
Methods: In this ongoing observational Dutch multicenter study (600 pts to be enrolled) blood was drawn at admission. Values of sFlt-1 and PlGF were measured postpartum using the automated Elecsys system to prevent influence of this information on decision-making of the treating physicians and the defining time point of delivery. Clinical characteristics and pregnancy outcomes were retrieved from medical records. Cutoffs of < 33 to rule out and > 85 to rule in the occurrence of delivery for selected time points were used.
Results: We have included 412 patients, so far complete data of 147 patients (age 18 to 48 yrs. singleton pregnancies, median pregnancy duration 32 weeks (range 20-36 weeks) is available. At time of inclusion 67 pregnancies were complicated with PE, of which 12 with superimposed PE, 8 with HELLP, 20 with gestational hypertension (GH) and 60 without pregnancy induced hypertension (PIH). The median (range) ratio in patients who delivered within 7 days was 146 (9-1803) compared to 14 (1-469) in those who delivered after > 7 days (p< 0.001). Delivery within 7 days occurred in 59% patients with a ratio > 85 compared to 7% with a ratio <33 (p=0.002) and 39% with a ratio 33-85 (p=0.048).
Conclusion: In this high risk group a low ratio is inversely correlated with prolongation of pregnancy.
Author Disclosures: L. Saleh: None. K. Verdonk: None. J.A.H. Danser: None. E.A.P. Steegers: None. H. Russcher: None. A.H. van den Meiracker: None. W. Visser: None.
- © 2015 by American Heart Association, Inc.