Abstract P164: White-coat Hypertension is a Factor Relating Postural Blood Pressure Dysregulation and Cardiovascular Risks
Backgrounds: Postural blood pressure (BP) dysregulation particularly orthostatic hypotension is a phenomenon that is frequently observed in elderly persons and has been reported to be a prognostic factor for incidence of cardiovascular diseases and mortality. White-coat and masked hypertension are another indices of blood pressure dysregulation and were also known to be a risk factor for cardiovascular outcomes. However, relationship between these common phenomena is yet unclear. Here we conducted a cross-sectional study to clarify the relationships.
Methods: Study subjects were 818 general persons. Homed BP was calculated from ambulatory monitored BPs as a mean of BPs measured during 1 hour after wake up. Orthostatic BP change was measured at 1 and 3 minutes after standing up and a maximum BP difference was used in the analysis.
Results: Home-to-clinic SBP differences were linearly and inversely associated with orthostatic SBP change (r=-0.321, p<0.001). Therefore, white-coat hypertensive subjects (10.3%, -9.3±13.3 mmHg) showed larger orthostatic BP decline than normotensive subjects (30.9%, -3.0±11.1 mmHg) and masked hypertensive subjects (24.7%, -0.4±12.1 mmHg, p<0.001). Home-to-clinic SBP differences (β=-0.150, p<0.001), but not orthostatic SBP change (β=-0.046, p=0.169), was significantly associated with carotid hypertrophy independently of basic covariates including clinic SBP.
Conclusion: Home-to-clinic SBP differences may be partially involved in the prognostic significance of orthostatic hypotension.
Author Disclosures: Y. Tabara: None. M. Igase: None. T. Miki: None. K. Kohara: None.
- © 2015 by American Heart Association, Inc.