Klotho and Pulmonary Hypertension
Spinning a Yarn or the Thread of Life?
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
See related article, pp 1255–1263
In the ancient Greek mythology, Klotho was the youngest of the 3 Fates responsible for spinning the thread of human life. Her sister Lachesis was thought to draw the lots and determine how long one lives by measuring the thread of life, and her other sister Atropos chose how someone dies by cutting the thread of life with her shears. Klotho was the youngest, and she had the power to make major decisions in not only choosing who was born but also deciding if a mortal should be saved or put to death. The 3 Fates (or the Moirai) were believed to appear 3 nights after a child’s birth to determine the course of its life.
When a new gene, thought to be involved in the suppression of ageing, was discovered in 1997,1 it was named Klotho after the youngest sister of these 3 Fates. In their article, Varshney et al2 report that …