Relevant Fetal Epigenetic Modifications Result From a Diabetic Intrauterine Environment
Healthy Aging Starts With a Healthy Pregnancy
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See related article, p 911–920
Twenty years ago, Barker1 reported an epidemiological observation that the in utero environment can affect late-onset diseases, such as coronary heart disease, through fetal malnourishment. Subsequent molecular studies demonstrated persistent changes in metabolic parameters that could predispose an individual to diabetes mellitus, metabolic syndrome, and cardiovascular disease. In this issue of Hypertension, Golic et al2 present an interesting study that combines these 2 aspects in an animal model, showing a direct correlation between the intrauterine milieu and subsequent epigenetic modifications.
The intrauterine environment and its impact on gene expression represent one of the most interesting aspects currently under investigation for the future risk of cardiovascular and metabolic …