Skip to main content
  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

  • Home
  • About this Journal
    • General Statistics
    • Editorial Board
    • Editors
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
    • Acknowledgment of Reviewers
    • Clinical Implications
    • Clinical-Pathological Conferences
    • Controversies in Hypertension
    • Editors' Picks
    • Guidelines Debate
    • Meeting Abstracts
    • Recent Advances in Hypertension
    • SPRINT Trial: the Conversation Continues
  • Resources
    • Instructions to Reviewers
    • Instructions for Authors
    • →Article Types
    • → Submission Guidelines
      • Research Guidelines
        • Minimum Information About Microarray Data Experiments (MIAME)
      • Abstract
      • Acknowledgments
      • Clinical Implications (Only by invitation)
      • Conflict(s) of Interest/Disclosure(s) Statement
      • Figure Legends
      • Figures
      • Novelty and Significance: 1) What Is New, 2) What Is Relevant?
      • References
      • Sources of Funding
      • Tables
      • Text
      • Title Page
      • Online/Data Supplement
    • →Tips for Easier Manuscript Submission
    • → General Instructions for Revised Manuscripts
      • Change of Authorship Form
    • → Costs to Authors
    • → Open Access, Repositories, & Author Rights Q&A
    • Permissions to Reprint Figures and Tables
    • Journal Policies
    • Scientific Councils
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
  • Facebook
  • Twitter

  • My alerts
  • Sign In
  • Join

  • Advanced search

Header Publisher Menu

  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

Hypertension

  • My alerts
  • Sign In
  • Join

  • Facebook
  • Twitter
  • Home
  • About this Journal
    • General Statistics
    • Editorial Board
    • Editors
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
    • Acknowledgment of Reviewers
    • Clinical Implications
    • Clinical-Pathological Conferences
    • Controversies in Hypertension
    • Editors' Picks
    • Guidelines Debate
    • Meeting Abstracts
    • Recent Advances in Hypertension
    • SPRINT Trial: the Conversation Continues
  • Resources
    • Instructions to Reviewers
    • Instructions for Authors
    • →Article Types
    • → Submission Guidelines
    • →Tips for Easier Manuscript Submission
    • → General Instructions for Revised Manuscripts
    • → Costs to Authors
    • → Open Access, Repositories, & Author Rights Q&A
    • Permissions to Reprint Figures and Tables
    • Journal Policies
    • Scientific Councils
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
Original Article

Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone

Jenifer M. Brown, Jonathan S. Williams, James M. Luther, Rajesh Garg, Amanda E. Garza, Luminita H. Pojoga, Daniel T. Ruan, Gordon H. Williams, Gail K. Adler, Anand Vaidya
Download PDF
https://doi.org/10.1161/HYPERTENSIONAHA.113.01910
Hypertension. 2013;HYPERTENSIONAHA.113.01910
Originally published November 4, 2013
Jenifer M. Brown
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan S. Williams
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James M. Luther
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rajesh Garg
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Amanda E. Garza
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Luminita H. Pojoga
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel T. Ruan
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gordon H. Williams
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gail K. Adler
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anand Vaidya
From the Division of Endocrinology, Diabetes, and Hypertension (J.M.B., J.S.W., R.G., A.E.G., L.H.P., G.H.W., G.K.A., A.V.) and Department of Surgery (D.T.R.), Brigham and Women’s Hospital and Harvard Medical School, Boston, MA; and Departments of Medicine and Pharmacology, Vanderbilt University Medical Center, Nashville, TN (J.M.L.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Supplemental Materials
  • Info & Metrics
  • eLetters

Jump to

  • Article
  • Supplemental Materials
  • Info & Metrics
  • eLetters
Loading

Abstract

Observational studies in primary hyperaldosteronism suggest a positive relationship between aldosterone and parathyroid hormone (PTH); however, interventions to better characterize the physiological relationship between the renin–angiotensin–aldosterone system (RAAS) and PTH are needed. We evaluated the effect of individual RAAS components on PTH using 4 interventions in humans without primary hyperaldosteronism. PTH was measured before and after study (1) low-dose angiotensin II (Ang II) infusion (1 ng/kg per minute) and captopril administration (25 mg×1); study (2) high-dose Ang II infusion (3 ng/kg per minute); study (3) blinded crossover randomization to aldosterone infusion (0.7 µg/kg per hour) and vehicle; and study (4) blinded randomization to spironolactone (50 mg/daily) or placebo for 6 weeks. Infusion of Ang II at 1 ng/kg per minute acutely increased aldosterone (+148%) and PTH (+10.3%), whereas Ang II at 3 ng/kg per minute induced larger incremental changes in aldosterone (+241%) and PTH (+36%; P<0.01). Captopril acutely decreased aldosterone (−12%) and PTH (−9.7%; P<0.01). In contrast, aldosterone infusion robustly raised serum aldosterone (+892%) without modifying PTH. However, spironolactone therapy during 6 weeks modestly lowered PTH when compared with placebo (P<0.05). In vitro studies revealed the presence of Ang II type I and mineralocorticoid receptor mRNA and protein expression in normal and adenomatous human parathyroid tissues. We observed novel pleiotropic relationships between RAAS components and the regulation of PTH in individuals without primary hyperaldosteronism: the acute modulation of PTH by the RAAS seems to be mediated by Ang II, whereas the long-term influence of the RAAS on PTH may involve aldosterone. Future studies to evaluate the impact of RAAS inhibitors in treating PTH-mediated disorders are warranted.

  • aldosterone
  • calcium
  • parathyroid hormone
  • renin-angiotensin system
  • spironolactone
  • vitamin D
  • Received June 21, 2013.
  • Revision received July 7, 2013.
  • Accepted October 8, 2013.
  • © 2013 American Heart Association, Inc.
Back to top
Next Article

Current Issue

Hypertension
May 2018, Volume 71, Issue 5
  • Table of Contents
Next Article

Jump to

  • Article
  • Supplemental Materials
  • Info & Metrics
  • eLetters

Article Tools

  • Print
  • Citation Tools
    Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone
    Jenifer M. Brown, Jonathan S. Williams, James M. Luther, Rajesh Garg, Amanda E. Garza, Luminita H. Pojoga, Daniel T. Ruan, Gordon H. Williams, Gail K. Adler and Anand Vaidya
    Hypertension. 2013;HYPERTENSIONAHA.113.01910, originally published November 4, 2013
    https://doi.org/10.1161/HYPERTENSIONAHA.113.01910

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
  • Article Alerts
    Log in to Email Alerts with your email address.
  • Save to my folders

Share this Article

  • Email

    Thank you for your interest in spreading the word on Hypertension.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone
    (Your Name) has sent you a message from Hypertension
    (Your Name) thought you would like to see the Hypertension web site.
  • Share on Social Media
    Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone
    Jenifer M. Brown, Jonathan S. Williams, James M. Luther, Rajesh Garg, Amanda E. Garza, Luminita H. Pojoga, Daniel T. Ruan, Gordon H. Williams, Gail K. Adler and Anand Vaidya
    Hypertension. 2013;HYPERTENSIONAHA.113.01910, originally published November 4, 2013
    https://doi.org/10.1161/HYPERTENSIONAHA.113.01910
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Related Articles

Cited By...

Subjects

  • Basic, Translational, and Clinical Research
    • Clinical Studies

Hypertension

  • About Hypertension
  • Instructions for Authors
  • AHA CME
  • Guidelines and Statements
  • Permissions
  • Journal Policies
  • Email Alerts
  • Open Access Information
  • AHA Journals RSS
  • AHA Newsroom

Editorial Office Address:
7272 Greenville Ave.
Dallas, TX 75231
email: hypertension@heart.org

Information for:
  • Advertisers
  • Subscribers
  • Subscriber Help
  • Institutions / Librarians
  • Institutional Subscriptions FAQ
  • International Users
American Heart Association Learn and Live
National Center
7272 Greenville Ave.
Dallas, TX 75231

Customer Service

  • 1-800-AHA-USA-1
  • 1-800-242-8721
  • Local Info
  • Contact Us

About Us

Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The need for our work is beyond question. Find Out More about the American Heart Association

  • Careers
  • SHOP
  • Latest Heart and Stroke News
  • AHA/ASA Media Newsroom

Our Sites

  • American Heart Association
  • American Stroke Association
  • For Professionals
  • More Sites

Take Action

  • Advocate
  • Donate
  • Planned Giving
  • Volunteer

Online Communities

  • AFib Support
  • Garden Community
  • Patient Support Network
  • Professional Online Network

Follow Us:

  • Follow Circulation on Twitter
  • Visit Circulation on Facebook
  • Follow Circulation on Google Plus
  • Follow Circulation on Instagram
  • Follow Circulation on Pinterest
  • Follow Circulation on YouTube
  • Rss Feeds
  • Privacy Policy
  • Copyright
  • Ethics Policy
  • Conflict of Interest Policy
  • Linking Policy
  • Diversity
  • Careers

©2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a qualified 501(c)(3) tax-exempt organization.
*Red Dress™ DHHS, Go Red™ AHA; National Wear Red Day ® is a registered trademark.

  • PUTTING PATIENTS FIRST National Health Council Standards of Excellence Certification Program
  • BBB Accredited Charity
  • Comodo Secured