Skip to main content
  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

  • Home
  • About this Journal
    • General Statistics
    • Editorial Board
    • Editors
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
    • Acknowledgment of Reviewers
    • Clinical Implications
    • Clinical-Pathological Conferences
    • Controversies in Hypertension
    • Editors' Picks
    • Guidelines Debate
    • Meeting Abstracts
    • Recent Advances in Hypertension
    • SPRINT Trial: the Conversation Continues
  • Resources
    • Instructions to Reviewers
    • Instructions for Authors
    • →Article Types
    • → Submission Guidelines
      • Research Guidelines
        • Minimum Information About Microarray Data Experiments (MIAME)
      • Abstract
      • Acknowledgments
      • Clinical Implications (Only by invitation)
      • Conflict(s) of Interest/Disclosure(s) Statement
      • Figure Legends
      • Figures
      • Novelty and Significance: 1) What Is New, 2) What Is Relevant?
      • References
      • Sources of Funding
      • Tables
      • Text
      • Title Page
      • Online/Data Supplement
    • →Tips for Easier Manuscript Submission
    • → General Instructions for Revised Manuscripts
      • Change of Authorship Form
    • → Costs to Authors
    • → Open Access, Repositories, & Author Rights Q&A
    • Permissions to Reprint Figures and Tables
    • Journal Policies
    • Scientific Councils
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
  • Facebook
  • Twitter

  • My alerts
  • Sign In
  • Join

  • Advanced search

Header Publisher Menu

  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

Hypertension

  • My alerts
  • Sign In
  • Join

  • Facebook
  • Twitter
  • Home
  • About this Journal
    • General Statistics
    • Editorial Board
    • Editors
    • Information for Advertisers
    • Author Reprints
    • Commercial Reprints
    • Customer Service and Ordering Information
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • AHA Guidelines and Statements
    • Acknowledgment of Reviewers
    • Clinical Implications
    • Clinical-Pathological Conferences
    • Controversies in Hypertension
    • Editors' Picks
    • Guidelines Debate
    • Meeting Abstracts
    • Recent Advances in Hypertension
    • SPRINT Trial: the Conversation Continues
  • Resources
    • Instructions to Reviewers
    • Instructions for Authors
    • →Article Types
    • → Submission Guidelines
    • →Tips for Easier Manuscript Submission
    • → General Instructions for Revised Manuscripts
    • → Costs to Authors
    • → Open Access, Repositories, & Author Rights Q&A
    • Permissions to Reprint Figures and Tables
    • Journal Policies
    • Scientific Councils
    • AHA Journals RSS Feeds
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
Original Article

Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline

The Ohasama Study

Akihiro Matsumoto, Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Mikio Hirano, Ryusuke Inoue, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Aya Hosokawa, Kazuhito Totsune, Haruhisa Hoshi, Toru Hosokawa, Hiroshi Sato, Yutaka Imai
Download PDF
https://doi.org/10.1161/HYPERTENSIONAHA.113.01819
Hypertension. 2014;HYPERTENSIONAHA.113.01819
Originally published March 31, 2014
Akihiro Matsumoto
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michihiro Satoh
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Masahiro Kikuya
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takayoshi Ohkubo
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mikio Hirano
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ryusuke Inoue
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takanao Hashimoto
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Azusa Hara
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takuo Hirose
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Taku Obara
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hirohito Metoki
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kei Asayama
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aya Hosokawa
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazuhito Totsune
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Haruhisa Hoshi
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Toru Hosokawa
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hiroshi Sato
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yutaka Imai
From the Department of Clinical Pharmacology and Therapeutics (A.M., T.Hashimoto, H.S.), Department of Preventive Medicine and Epidemiology (M.K., T.Obara), and Department of Community Medical Supports (H.M.), Tohoku Medical Megabank Organization, Department of Planning for Drug Development and Clinical Evaluation (T.Hirose, K.A., K.T., Y.I.), Department of Human Development, Faculty of Education (T.Hosokawa), Tohoku University, Sendai, Japan; Department of Pharmacy (M.S., T.Obara), Medical Information Technology Center (R.I.), Tohoku University Hospital, Sendai, Japan; Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (T.Ohkubo); The Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Japan (M.H.); Department of Pharmacy, Sendai Open Hospital, Sendai, Japan (T.Hashimoto); Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, Studies Coordinating Centre, University of Leuven, Leuven, Belgium (A.Hara, K.A); Early Development and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, Paris, France (T.Hirose); Department of Career Design, Sendai Seiyo Gakuin College, Sendai, Japan (A.Hosokawa); Department of Social Welfare, Tohoku Fukushi University, Sendai, Japan (K.T.); and Department of Medicine, Ohasama Hospital, Iwate, Japan (H.H.).
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Supplemental Materials
  • Info & Metrics
  • eLetters

Jump to

  • Article
  • Supplemental Materials
  • Info & Metrics
  • eLetters
Loading

Abstract

Although an association between high blood pressure and cognitive decline has been reported, no studies have investigated the association between home blood pressure and cognitive decline. Home blood pressure measurements can also provide day-to-day blood pressure variability calculated as the within-participant SD. The objectives of this prospective study were to clarify whether home blood pressure has a stronger predictive power for cognitive decline than conventional blood pressure and to compare the predictive power of the averaged home blood pressure with day-to-day home blood pressure variability for cognitive decline. Of 485 participants (mean age, 63 years) who did not have cognitive decline (defined as Mini-Mental State Examination score, <24) initially, 46 developed cognitive decline after a median follow-up of 7.8 years. Each 1-SD increase in the home systolic blood pressure value showed a significant association with cognitive decline (odds ratio, 1.48; P=0.03). However, conventional systolic blood pressure was not significantly associated with cognitive decline (odds ratio, 1.24; P=0.2). The day-to-day variability in systolic blood pressure was significantly associated with cognitive decline after including home systolic blood pressure in the same model (odds ratio, 1.51; P=0.02), whereas the odds ratio of home systolic blood pressure remained positive, but it was not significant. Home blood pressure measurements can be useful for predicting future cognitive decline because they can provide information not only on blood pressure values but also on day-to-day blood pressure variability.

  • blood pressure
  • cohort studies
  • mild cognitive impairment
  • Received July 1, 2013.
  • Revision received July 15, 2013.
  • Accepted March 3, 2014.
  • © 2014 American Heart Association, Inc.
Back to top
Next Article

Current Issue

Hypertension
May 2018, Volume 71, Issue 5
  • Table of Contents
Next Article

Jump to

  • Article
  • Supplemental Materials
  • Info & Metrics
  • eLetters

Article Tools

  • Print
  • Citation Tools
    Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline
    Akihiro Matsumoto, Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Mikio Hirano, Ryusuke Inoue, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Aya Hosokawa, Kazuhito Totsune, Haruhisa Hoshi, Toru Hosokawa, Hiroshi Sato and Yutaka Imai
    Hypertension. 2014;HYPERTENSIONAHA.113.01819, originally published March 31, 2014
    https://doi.org/10.1161/HYPERTENSIONAHA.113.01819

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
  • Article Alerts
    Log in to Email Alerts with your email address.
  • Save to my folders

Share this Article

  • Email

    Thank you for your interest in spreading the word on Hypertension.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline
    (Your Name) has sent you a message from Hypertension
    (Your Name) thought you would like to see the Hypertension web site.
  • Share on Social Media
    Day-to-Day Variability in Home Blood Pressure Is Associated With Cognitive Decline
    Akihiro Matsumoto, Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Mikio Hirano, Ryusuke Inoue, Takanao Hashimoto, Azusa Hara, Takuo Hirose, Taku Obara, Hirohito Metoki, Kei Asayama, Aya Hosokawa, Kazuhito Totsune, Haruhisa Hoshi, Toru Hosokawa, Hiroshi Sato and Yutaka Imai
    Hypertension. 2014;HYPERTENSIONAHA.113.01819, originally published March 31, 2014
    https://doi.org/10.1161/HYPERTENSIONAHA.113.01819
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Related Articles

Cited By...

Subjects

  • Stroke
    • Cerebrovascular Disease/Stroke

Hypertension

  • About Hypertension
  • Instructions for Authors
  • AHA CME
  • Guidelines and Statements
  • Permissions
  • Journal Policies
  • Email Alerts
  • Open Access Information
  • AHA Journals RSS
  • AHA Newsroom

Editorial Office Address:
7272 Greenville Ave.
Dallas, TX 75231
email: hypertension@heart.org

Information for:
  • Advertisers
  • Subscribers
  • Subscriber Help
  • Institutions / Librarians
  • Institutional Subscriptions FAQ
  • International Users
American Heart Association Learn and Live
National Center
7272 Greenville Ave.
Dallas, TX 75231

Customer Service

  • 1-800-AHA-USA-1
  • 1-800-242-8721
  • Local Info
  • Contact Us

About Us

Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The need for our work is beyond question. Find Out More about the American Heart Association

  • Careers
  • SHOP
  • Latest Heart and Stroke News
  • AHA/ASA Media Newsroom

Our Sites

  • American Heart Association
  • American Stroke Association
  • For Professionals
  • More Sites

Take Action

  • Advocate
  • Donate
  • Planned Giving
  • Volunteer

Online Communities

  • AFib Support
  • Garden Community
  • Patient Support Network
  • Professional Online Network

Follow Us:

  • Follow Circulation on Twitter
  • Visit Circulation on Facebook
  • Follow Circulation on Google Plus
  • Follow Circulation on Instagram
  • Follow Circulation on Pinterest
  • Follow Circulation on YouTube
  • Rss Feeds
  • Privacy Policy
  • Copyright
  • Ethics Policy
  • Conflict of Interest Policy
  • Linking Policy
  • Diversity
  • Careers

©2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a qualified 501(c)(3) tax-exempt organization.
*Red Dress™ DHHS, Go Red™ AHA; National Wear Red Day ® is a registered trademark.

  • PUTTING PATIENTS FIRST National Health Council Standards of Excellence Certification Program
  • BBB Accredited Charity
  • Comodo Secured