Dr Lewis Kitchener Dahl, the Dahl Rats, and the “Inconvenient Truth” About the Genetics of Hypertension
Synopsis— Lewis K. Dahl is regarded as an iconic figure in the field of hypertension research. During the 1960s and 1970s, he published several seminal articles in the field that shed light on the relationship between salt and hypertension. Further, the Dahl rat models of hypertension that he developed by a selective breeding strategy are among the most widely used models for hypertension research. To this day, genetic studies using this model are ongoing in our laboratory. Although Dr Dahl is known for his contributions to the field of hypertension, little, if any, of his personal history is documented. This article details a short biography of Dr Lewis Dahl, the history behind the development of the Dahl rats, and presents an overview of the results obtained through the genetic analysis of the Dahl rat as an experimental model to study the inheritance of hypertension.
- Received November 25, 2014.
- Revision received December 5, 2014.
- Accepted December 29, 2014.
- © 2015 American Heart Association, Inc.