Association of Central Versus Brachial Blood Pressure With Target-Organ Damage
Systematic Review and Meta-Analysis
Accumulating evidence suggests that central blood pressure (BP) may reflect the hemodynamic stress on target organs more accurately than brachial BP. A systematic review assessing the relationship of central versus brachial BP with preclinical target-organ damage was performed. Meta-analysis of cross-sectional data showed that central compared with brachial systolic BP was more closely associated with (1) left ventricular mass index (12 studies, n=6431; weighted age [SD], 49.9 [13.1] years; 51% hypertensives): pooled correlation coefficients r=0.30; 95% confidence interval (CI), 0.23–0.37 versus r=0.26; 95% CI, 0.19–0.33, respectively; P<0.01 for difference; (2) carotid intima-media thickness (7 studies, n=6136; weighted age, 55.6 [13.2] years; 48% hypertensives): r=0.27; 95% CI, 0.19–0.34 versus r=0.23; 95% CI, 0.16–0.30, respectively; P<0.01 for difference; (3) pulse-wave velocity (14 studies, n=3699; weighted age, 53.9 [13.3] years; 53% hypertensives): r=0.42; 95% CI, 0.37–0.47 versus r=0.39; 95% CI, 0.33–0.45, respectively; P<0.01 for difference. Four studies assessing urine albumin excretion (n=3718; weighted age, 56.4  years; 69% hypertensives) reported similar correlations (P=not significant) with central (r=0.22; 95% CI, 0.14–0.29) and brachial systolic BP (r=0.22; 95% CI, 0.12–0.32). Similar findings were observed for central compared with brachial pulse pressure in terms of relationship with target-organ damage. Metaregression analyses did not reveal any significant effect of age. In conclusion, central compared with brachial BP seems to be more strongly associated with most of the investigated indices of preclinical organ damage.
- aortic blood pressure
- carotid intima-media thickness
- left ventricular hypertrophy
- pulse wave velocity
- Received June 29, 2015.
- Revision received July 14, 2015.
- Accepted October 28, 2015.
- © 2015 American Heart Association, Inc.