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Original Article

Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension

Luciana C. Veiras, Jiyang Han, Donna L. Ralph, Alicia A. McDonough
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https://doi.org/10.1161/HYPERTENSIONAHA.116.07389
Hypertension. 2016;HYPERTENSIONAHA.116.07389
Originally published September 6, 2016
Luciana C. Veiras
From the Department of Cell and Neurobiology, Keck School of Medicine of USC, Los Angeles, CA.
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Jiyang Han
From the Department of Cell and Neurobiology, Keck School of Medicine of USC, Los Angeles, CA.
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Donna L. Ralph
From the Department of Cell and Neurobiology, Keck School of Medicine of USC, Los Angeles, CA.
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Alicia A. McDonough
From the Department of Cell and Neurobiology, Keck School of Medicine of USC, Los Angeles, CA.
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Abstract

Angiotensin II (AngII) hypertension increases distal tubule Na-Cl cotransporter (NCC) abundance and phosphorylation (NCCp), as well as epithelial Na+ channel abundance and activating cleavage. Acutely raising plasma [K+] by infusion or ingestion provokes a rapid decrease in NCCp that drives a compensatory kaliuresis. The first aim tested whether acutely raising plasma [K+] with a single 3-hour 2% potassium meal would lower NCCp in Sprague–Dawley rats after 14 days of AngII (400 ng/kg per minute). The potassium-rich meal neither decreased NCCp nor increased K+ excretion. AngII-infused rats exhibited lower plasma [K+] versus controls (3.6±0.2 versus 4.5±0.1 mmol/L; P<0.05), suggesting that AngII-mediated epithelial Na+ channel activation provokes K+ depletion. The second aim tested whether doubling dietary potassium intake from 1% (A1K) to 2% (A2K) would prevent K+ depletion during AngII infusion and, thus, prevent NCC accumulation. A2K-fed rats exhibited normal plasma [K+] and 2-fold higher K+ excretion and plasma [aldosterone] versus A1K. In A1K rats, NCC, NCCpS71, and NCCpT53 abundance increased 1.5- to 3-fold versus controls (P<0.05). The rise in NCC and NCCp abundance was prevented in the A2K rats, yet blood pressure did not significantly decrease. Epithelial Na+ channel subunit abundance and cleavage increased 1.5- to 3-fold in both A1K and A2K; ROMK (renal outer medulla K+ channel abundance) abundance was unaffected by AngII or dietary K+. In summary, the accumulation and phosphorylation of NCC seen during chronic AngII infusion hypertension is likely secondary to potassium deficiency driven by epithelial Na+ channel stimulation.

  • aldosterone-sensitive distal nephron
  • angiotensin II hypertension
  • dietary potassium
  • hypokalemia
  • kaliuresis
  • Received February 22, 2016.
  • Revision received March 8, 2016.
  • Accepted May 27, 2016.
  • © 2016 American Heart Association, Inc.
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    Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension
    Luciana C. Veiras, Jiyang Han, Donna L. Ralph and Alicia A. McDonough
    Hypertension. 2016;HYPERTENSIONAHA.116.07389, originally published September 6, 2016
    https://doi.org/10.1161/HYPERTENSIONAHA.116.07389

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    Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension
    Luciana C. Veiras, Jiyang Han, Donna L. Ralph and Alicia A. McDonough
    Hypertension. 2016;HYPERTENSIONAHA.116.07389, originally published September 6, 2016
    https://doi.org/10.1161/HYPERTENSIONAHA.116.07389
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