Cardiovascular Risk Factors Accelerate Progression of Vascular Aging in the General Population Results From the CRAVE Study (Cardiovascular Risk Factors Affecting Vascular Age)
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- Published on September 28, 2017Target organ damage as an aging biomarker
- Hongwei Ji, Cardiac Physician, Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
Though there is no generally accepted best practice on how to assess vascular age, vascular aging assessed by vascular phenotype is widely used [1, 2] And vascular aging, as a tissue biomarker, reflects vascular structural and functional changes due to risk factors. Dimitrios et al. innovatively used the number of risk factors as an influential factor which is associated with the change of vascular aging biomarker (cf-PWV). This study adds evidence to the vascular aging field that cardiovascular risk factors contribute to the progression of vascular aging.
In fact, vascular aging is a tissue-level problem. For the elderly, the organ-level aging should be stressed. Some organ-level aging has occurred and affected the organ’s function, like target organ damage (TOD). Because TOD integrates the cumulative effects of CV risk factors with aging . More researches in this aspect may help to understand this problem.
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2. Niiranen TJ, Lyass A, Larson MG, Hamburg NM, Benjamin EJ, Mitchell GF, Vasan RS: Prevalence, Correlates, and Prognosis of Healthy Vascular Aging in a Western Community-Dwelling Cohort: The Framingham Heart Study. Hypertension 2017, 70(2):267-274.
3. Nilsson PM, Boutouyrie P, Laurent S: Vascular aging: A tale of EVA and ADAM in cardiovascular risk assessment and prevention. Hypertension 2009, 54(1):3-10.Competing Interests: None declared.