On the cover: Two different mechanisms of adipocyte differentiation. (A) Differentiation of mesenchymal stem cells (MSCs) and effect of angiotensin II type-1 receptor blocker (ARB) on this adipogenesis. In differentiated adipocytes, secretion of inflammatory adipocytokines, such as TNF-α, is decreased, and beneficial cytokines, such as adiponectin, are increased, whereas the opposite is observed in MSCs. Treatment with an ARB inhibits adipogenesis. Such treated adipocytes may transdifferentiate into other types of cells. (B) Differentiation of preadipocytes and effect of ARB on this adipogenesis. Preadipocytes treated with an ARB differentiate into small adipocytes and secrete decreased inflammatory cytokines, such as TNF-α, and increased beneficial cytokines, such as adiponectin, and are regarded as well differentiated adipocytes. In contrast, lack of RAS blockade has the opposite effect on secretion in large adipocytes, regarded as poorly differentiated adipocytes. (See page 1020.)