On the cover: Dihydropyridine can dock into the mineralocorticoid receptor (MR) crystal structure. A, Dihydropyridine consensus docking pose in MR ligand binding domain (LBD) illustrated by nimodipine. The consensus pose is characterized by the dihydropyridine 1-NH hydrogen bond donation to Asn770, with the 4-aryl group residing in the A-ring pocket. Additional hydrogen bonds (as seen here to Arg817, Ser810, and Cys849) are frequently seen but are not required to obtain this as the favored pose. B, Representative induced fit docking model of eplerenone in MR S810L. A reasonable pose is obtained with correct steroid orientation, ester in α-face pocket, and similar interaction with Asn770 amide as seen in the S810L crystal structures with bound spironolactone. Root mean squared distance of steroid ring atoms in this pose relative to the spironolactone crystal structure is 0.53 Å. C, Overlay of eplerenone and nimodipine docked poses. The dihydropyridine 4-aryl group overlays the eplerenone A-ring, and both eplerenone and the dihydropyridine place ester groups into the α-face pocket. The dihydropyridine however neither occupies steroid D-ring volume nor interacts with Thr745 or other Helix 11 residues. (See page 746.)