On the cover: Characterization of cardiomyocyte vacuolar morphology by assessment of apoptosis (TUNEL stain, 2 left panels) and autophagy (HcRed-LC3, 2 right panels) in Ad-AT1A-infected neonatal cardiomyocytes. Left panels, No evidence of apoptosis by TUNEL staining in Ang II-stimulated Ad-AT1A-infected cells displaying vacuolar morphology. Positive control cells (H2O2-treated myocytes, 200 μmol/L, 5 hours) displayed clear evidence of apoptosis by TUNEL staining. Right panels, Diffuse cytosolic and nuclear localization of HcRed-LC3 in neonatal cardiomyocytes under basal growth conditions. Punctate localization of HcRed-LC3 in Ang II-stimulated Ad-AT1A-infected cardiomyocytes displaying vacuolar morphology. (See page 1032.)
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