Table.

Left Ventricular Hemodynamic Parameters Recorded by Cardiac Catheterization in Control, PAH, and PAH+DHEA Rats

ParameterNormalSU/Hx/NxSU/Hx/Nx+DHEA
BPsystole, mm Hg135.8±16.4158.4±5.3151.5±6.8
BPdiastole, mm Hg99.6±10.7126.2±2.8*117.5±5.2
CI, mL/min per kilogram118.8±12.265.6±6.7*111.1±9.6
End-systolic volume, μL107.6±22.4114.7±21.6114.0±22.3
End-diastolic volume, μL178.5±13.1144.9±3.9*163.1±18.0
End-systolic pressure, mm Hg134.6±8.2161.1±7.2*150.2±4.8
Stroke volume, μL93.3±10.063.2±4.1*80.3±3.4
EF53±752±852±6
dV/dt max, μL/s3727±7833424±4833455±240
dV/dt min, μL/s−3327±171−4692±974−3834±546
V@dP/dt max, μL182.3±13.6154.0±10.2164.6±19.0
V@dP/dt min, μL106.8±20.1116.8±16.3113.3±21.0
Tau_w, ms9.1±0.810.4±0.89.6±0.6
Maximal power, mW50.1±2.273.4±13.0*45.9±3.4
Preload adjusted maximal power, mW/μL216.8±2.835.6±5.2*20.6±5.0
  • BP indicates blood pressure; CI, cardiac index; DHEA, dehydroepiandrosterone; EF, ejection fraction; Hx, hypoxia; Nx, normoxia; PAH, pulmonary arterial hypertension; and SU, Sugen.

  • * P<0.05 vs normal.

  • P<0.05 vs SU/Hx/Nx.